Table 2

Comparison of antibiotic use as per NICE guidance vs recommendations of the SRC in the study population

Kaiser Permanente SRCTotal
(% of study cohort)
No antibioticsAntibiotics
Current guidance (NICE)No antibiotics301163017 (84)
Antibiotics426150576 (16)
Total (% of study cohort)3437 (95.7)156 (4.3)3593 (100)
  • Sixteen per cent antibiotics as per NICE compared with 4.3% as per SRC. Absolute difference 11.7% (95% CI 10.64 to 12.74), p<0.0001, McNemar’s test for matched proportions.

  • NICE, National Institute for Health and Care Excellence; SRC, sepsis risk calculator.