Sedation group n=42 | No sedation group n=36 | P values | |
Incidence of desaturation* | 38/42 (91%) | 25/36 (69%) | 0.023 |
Incidence of hypotension* | 9/30 (30%) | 2/17 (12%) | 0.282 |
Treatment for hypotension* | 3/9 (33%) | 0/2 (0%) | 1.000 |
Blood pressure (mean mm Hg)† | 0.145 | ||
Before MIST | 37±8 | 38±7 | |
During MIST | 35±7 | 39±5 | |
After MIST | 35±7 | 38±4 | |
Incidence of bradycardia* | 9/42 (21%) | 5/35 (14%) | 0.556 |
Heart rate (beats per minute)† | 0.002 | ||
Before MIST | 151±16 | 148±13 | |
During MIST | 143±14 | 147±13 | |
After MIST | 141±13 | 146±14 | |
Need for nIMV* | 39/42 (93%) | 17/36 (47%) | <0.001 |
Duration of needed nIMV (minutes)‡ | 7 (3–21) | 6 (3–12) | 0.274 |
Intubation during MIST* | 1/42 (2%) | 4/36 (11%) | 0.175 |
Intubation in 24 hours following MIST* | 10/42 (24%) | 6/36 (17%) | 0.576 |
Incidence of pneumothorax* | 3/42 (7%) | 1/36 (3%) | 0.620 |
Incidence of pulmonary haemorrhage* | 1/42 (2%) | 0/36 (0%) | 1.000 |
Intraventricular haemorrhage≥grade 3* | 2/42 (5%) | 0/36 (0%) | 0.497 |
Death* | 1/42 (2%) | 1/36 (3%) | 1.000 |
Data are presented as
*n (%) for categorical data.
†Mean±SD for parametric data.
‡Median (IQR) for non-parametric data.
MIST, minimal invasive surfactant therapy; nIMV, nasal intermittent mandatory ventilation.