Parental opinion on informed, waived and deferred consent n=600
| Level of agreement | Mean (SD) | Median (IQR) | P values*† | |||||
| Strongly disagree=1 n (%) | Disagree n (%) | Neither agree nor disagree n (%) | Agree n (%) | Strongly agree=5 n (%) | ||||
| I would agree to my baby participating in this study | <0.001 | |||||||
| Study 1a | 25 (4.2) | 70 (11.7) | 199 (33.2) | 265 (44.2) | 41 (6.8) | 3.4 (0.9) | 4 (3–4) | |
| Study 2a | 27 (4.5) | 89 (14.8) | 155 (25.8) | 273 (45.5) | 56 (9.3) | 3.4 (1.0) | 4 (3–4) | |
| Study 3b | 27 (4.5) | 73 (12.2) | 134 (22.3) | 284 (47.3) | 82 (13.7) | 3.5 (1.0) | 4 (3–4) | |
| Study 4a | 46 (7.7) | 82 (13.7) | 166 (27.7) | 273 (45.5) | 33 (5.5) | 3.3 (1.0) | 4 (3–4) | |
| In circumstances where there was not enough time to get consent, I would be happy for my baby to be enrolled in the trial and approached for consent after my baby was enrolled | <0.001 | |||||||
| Study 1a | 93 (15.5) | 217 (36.2) | 127 (21.2) | 146 (24.3) | 17 (2.8) | 2.6 (1.1) | 2 (2–4) | |
| Study 2a,c | 93 (15.5) | 177 (29.5) | 110 (18.3) | 185 (30.8) | 35 (5.8) | 2.8 (1.2) | 3 (2–4) | |
| Study 3b | 61 (10.2) | 116 (19.3) | 115 (19.2) | 235 (39.2) | 73 (12.2) | 3.2 (1.2) | 4 (2–4) | |
| Study 4c | 86 (14.3) | 161 (26.8) | 116 (19.3) | 207 (34.5) | 30 (5.0) | 2.9 (1.2) | 3 (2–4) | |
| I would be happy for my baby to be a participant in this study without it ever being discussed with me | <0.001 | |||||||
| Study 1a | 285 (47.5) | 216 (36.0) | 54 (9.0) | 37 (6.2) | 8 (1.3) | 1.8 (0.9) | 2 (1–2) | |
| Study 2b | 182 (30.3) | 222 (37.0) | 94 (15.7) | 86 (14.3) | 16 (2.7) | 2.2 (1.1) | 2 (1–3) | |
| Study 3c | 118 (19.7) | 153 (25.5) | 109 (18.2) | 170 (28.3) | 50 (8.3) | 2.8 (1.3) | 3 (2–4) | |
| Study 4d | 143 (23.8) | 193 (32.2) | 105 (17.5) | 136 (22.7) | 23 (3.8) | 2.5 (1.2) | 2 (2–4) | |
*From Friedman test.
†Studies with different superscript letters are significantly different based on Dunn-Bonferroni post hoc tests.