Documented benefits of volume-targeted ventilation. Data from Cochrane meta-analysis 2017 (Ref 2)
| Relative risk or mean difference | 95% CI | NNTB (95% CI) | |
| Death or BPD at 36 weeks PMA | 0.75 | 0.53 to 1.07 | NA |
| BPD at 36 weeks PMA | 0.73 | 0.59 to 0.89 | 8 (5 to 20) |
| Grade 3–4 IVH | 0.53 | 0.37 to 0.77 | 11 (7 to 25) |
| PVL ± severe IVH | 0.47 | 0.27 to 0.80 | 11 (7 to 33) |
| Pneumothorax | 0.52 | 0.31 to 0.87 | 20 (11 to 100) |
| Hypocapnia | 0.49 | 0.33 to 0.72 | 3 (2 to 5) |
| Days of mechanical ventilation | −1.35 | −1.83 to −0.86 |
BPD, bronchopulmonary dysplasia; PMA, postmenstrual age; IVH, intraventricular haemorrhage; PVL, periventricular leucomalacia; NNTB, number needed to benefit.