Predictor | Study – definition/threshold | Summary sensitivity (95% CI) | Summary specificity (95% CI) |
Physiological tests | |||
Vt | Kavvadia, 200028 – Vt >4 mL/kg Davidson, 200832 – Vt ≥4 mL/kg | 75 (59 to 87) | 28 (12 to 49) |
MVs | Fox, 199320 – %MVs after added dead space >140% Vento, 200430 – MVs <125 mL/kg/min for ≤8.1% of time Kamlin, 200631 – MVs >220 mL/kg/min Kamlin, 200631 – MVs/MVm >0.8 | 84 (77 to 90) | 71 (57 to 83) |
VI of breathing pattern | Kaczmarek, 201341 – VI of Ti Kaczmarek, 201341 – VI of Te Kaczmarek, 201341 – VI of Vt Kaczmarek, 201341 – VI of Ti/Ttot Kaczmarek, 201341 – VI of Vt/Ti | 100 (86 to 100) | 18 (7 to 38) |
Clinical tests | |||
SBT | Kamlin, 200631 – clinical definition Chawla, 201340 – clinical definition | 95 (87 to 99) | 62 (38 to 82) |
Composite tests | |||
SBT+VI of breathing pattern | Kaczmarek, 201341 – SBT+VI of Ti Kaczmarek, 201341 – SBT+VI of Te Kaczmarek, 201341 – SBT+VI of Vt Kaczmarek, 201341 – SBT+VI of Ti/Ttot Kaczmarek, 201341 – SBT+VI of Vt/Ti | 99 (97 to 100) | 73 (56 to 85) |
TTdi | Currie, 201136 – TTdi ≤0.15 Dimitriou, 201137 – TTdi ≤0.12 Bhat, 201644 – TTdi <0.08 | 86 (75 to 94) | 95 (75 to 100) |
TTmus | Currie, 201136 – TTmus ≤0.18 Dimitriou, 201137– TTmus ≤0.1 Bhat, 201644 – TTmus <0.19 | 94 (84 to 98) | 75 (51 to 91) |
Data for which two or more tests could be grouped are presented.
MVm, mechanical minute ventilation; MVs, spontaneous minute ventilation; SBT, spontaneous breathing trial; Te, expiratory time; Ti, inspiratory time; Ttdi, diaphragmatic tension time index; Ttmus, tension time index of respiratory muscles; Ttot, total breath time; VI, variability index; Vt , tidal volume; Vt/Ti, mean inspiratory flow.