Table 3

Meta-analysis of pooled outcome measures

StudiesParticipantsRR (95% CI)
Primary outcomes
 BPD 36 weeks PMA34180.81 (0.63 to 1.04)
 Combined BPD and mortality 36 weeks PMA34350.89 (0.65 to 1.21)
 Death before discharge34350.92 (0.51 to 1.65)
Secondary outcomes
 Failure to extubate44630.51 (0.37 to 0.70)
 Tachycardia55283.39 (1.50 to 7.64)
 NEC ≥ grade 245300.82 (0.36 to 1.90)
 SIP1741.00 (0.22 to 4.64)
 IVH > grade 245671.24 (0.65 to 2.36)
 Hyperglycemia2471.92 (0.47 to 7.94)
 ROP≥ grade 333900.60 (0.28 to 1.29)
Long term outcomes
 Mortality < 12 months CA23040.93 (0.47 to 1.85)
 Major disability at 12 months CA11900.58 (0.26 to 1.25)
 Death or disability at 12 months CA22071.19 (0.37 to 3.77)
 GQ at 12 months CA11904.40 (0.07 to 8.73)
  • Hyperglycaemia as defined by the original authors. Major disability defined as defined as having cerebral palsy, general quotient<75, bilateral blindness and/or deafness at 12 months corrected age.

  • RR, relative risk.