Study characteristics
| Author (date) | Setting | Location | Described study design | Definition | Results (CLABSI per 1000 central line days) |
| Almeida (2016)37 | Tertiary NICU | Portugal | Before/after | NEO-KISS | 14.1 to 10.4 |
| Arnts (2015)42 | Tertiary NICU | Netherlands | Prospective cohort | CDC | 12.9 to 4.7 (CI 1.25 to 11.23) |
| Bizzarro (2010)43 | Level IIIc 54 bed NICU | USA | Before/after | CDC | 8.44 to 1.7 (CI 0.08 to 0.45) |
| Bowen (2016)44 | 8 NICUs <29 weeks only | Australia | Before/after | Bloodstream infection (BSI) where a central line was in situ within 48 hours of removal of the central line, unless clearly identified source of infection | 9.9-5.4 |
| Ceballos (2013)26 | Level IIIb 50 bed NICU | USA | Before/after | CDC | 6.9 to 0 |
| Chandonnet (2012)45 | Level IIIc 24 bed NICU | USA | Before/after | CDC | 2.6 to 0.8 |
| Erdei (2015)22 | Level IIIc NICU | USA | Before/after | CDC | 4.1 to 0.94 |
| Fisher (2013)24 | 13 NNUs: 3 level II 10 level III | USA | Before/after | CDC | 3.94 to 1.16 |
| Kime (2011)46 | Level III NICU | USA | Before/after | 15.6-0 | |
| McMullan (2016)47 | Level V NICU | Australia | Retrospective cohort | Proven BSI associated with a central venous line, when a central line has been in use 48 hours before signs and symptoms of infection | 8.5 to 2.3 |
| Piazza (2016)21 | 17 IIIc NICUs >25 beds | USA | Before/after | CDC | 1.33 to 1.076 |
| Rallis (2016)48 | Level III NICU | Greece | Before/after | CDC | 12 to 3.4 |
| Resende (2011)49 | NICU | Brazil | Before/after | CDC | 24.1 to 14.9 |
| Rosenthal (2013)29 | 4 NICUs | El Salvador, Mexico, Phillipines, Tunisia | Before/after | CDC | 21.4 to 9.7 |
| Salm (2016)20 | 34 NICUs | Germany | Cohort study | NEO-KISS | 2.63 to 1.98 (per 1000 patient days) |
| Schulman (2011)27 | 18 NICUs | USA | Prospective cohort | CDC Definition change during study | 3.5 to 2.1 |
| Shepherd (2015)25 | 8 NICUs | USA | Before/after | CDC | 6 to 0.68 |
| Sinha (2016)19 | Level III NICU | UK | Before/after | BSI >48 hours after birth, with central line in situ, or 48 hours previously | 31.6 to 4.3 |
| Steiner (2015)50 | NICU | Austria | Before/after | NEO-KISS | 13.9 to 4.7 |
| Ting (2013)31 | NICU level III | Canada | Before/after | Canadian Nosocomial Infection Surveillance Program or National Healthcare Safety Network | 7.9 to 2.2 |
| Wang (2015)51 | NICU 110 very low birthweight infants | China | Case-control | Not provided | 3.1 control 0 intervention |
| Wilder (2016)52 | NICU, level IV, 36 beds | USA | Before/after | Not provided | 3.9 to 0.3 |
| Wirtschafter (2010)28 | 13 NICUs | USA | Before/after | CDC | 4.3 to 3.2 |
| Zhou (2015)53 | NICU | China | Before/after | CDC | 16.7 to 5.2 |
CDC, Centre for Disease Control.