Table 2

Study characteristics

Author (date)SettingLocationDescribed study designDefinitionResults (CLABSI per 1000 central line days)
Almeida (2016)37 Tertiary NICUPortugalBefore/afterNEO-KISS14.1 to 10.4
Arnts (2015)42 Tertiary NICUNetherlandsProspective cohortCDC12.9 to 4.7 (CI 1.25 to 11.23)
Bizzarro (2010)43 Level IIIc 54 bed NICUUSABefore/afterCDC8.44 to 1.7 (CI 0.08 to 0.45)
Bowen (2016)44 8 NICUs <29 weeks onlyAustraliaBefore/afterBloodstream infection (BSI) where a central line was in situ within 48 hours of removal of the central line, unless clearly identified source of infection9.9-5.4
Ceballos (2013)26 Level IIIb 50 bed NICUUSABefore/afterCDC6.9 to 0
Chandonnet (2012)45 Level IIIc 24 bed NICUUSABefore/afterCDC2.6 to 0.8
Erdei (2015)22 Level IIIc NICUUSABefore/afterCDC4.1 to 0.94
Fisher (2013)24 13 NNUs:
3 level II
10 level III
USABefore/afterCDC3.94 to 1.16
Kime (2011)46 Level III NICUUSABefore/after15.6-0
McMullan (2016)47 Level V NICUAustraliaRetrospective cohortProven BSI associated with a central venous line, when a central line has been in use 48 hours before signs and symptoms of infection8.5 to 2.3
Piazza (2016)21 17 IIIc NICUs
>25 beds
USABefore/afterCDC1.33 to 1.076
Rallis (2016)48 Level III NICUGreeceBefore/afterCDC12 to 3.4
Resende (2011)49 NICUBrazilBefore/afterCDC24.1 to 14.9
Rosenthal (2013)29 4 NICUsEl Salvador, Mexico, Phillipines, TunisiaBefore/afterCDC21.4 to 9.7
Salm (2016)20 34 NICUsGermanyCohort studyNEO-KISS2.63 to 1.98 (per 1000 patient days)
Schulman (2011)27 18 NICUsUSAProspective cohortCDC
Definition change during study
3.5 to 2.1
Shepherd (2015)25 8 NICUsUSABefore/afterCDC6 to 0.68
Sinha (2016)19 Level III NICUUKBefore/afterBSI >48 hours after birth, with central line in situ, or 48 hours previously31.6 to 4.3
Steiner (2015)50 NICUAustriaBefore/afterNEO-KISS13.9 to 4.7
Ting (2013)31 NICU level IIICanadaBefore/afterCanadian Nosocomial Infection Surveillance Program or National Healthcare Safety Network7.9 to 2.2
Wang (2015)51 NICU
110 very low birthweight infants
ChinaCase-controlNot provided3.1 control
0 intervention
Wilder (2016)52 NICU, level IV, 36 bedsUSABefore/afterNot provided3.9 to 0.3
Wirtschafter (2010)28 13 NICUsUSABefore/afterCDC4.3 to 3.2
Zhou (2015)53 NICUChinaBefore/afterCDC16.7 to 5.2
  • CDC, Centre for Disease┬áControl.