Three definitions of central line-associated bloodstream infection
| Source | Definition | Clinical signs | Laboratory markers |
| NEO-KISS39 | Laboratory-confirmed bloodstream infection (LCBI) with coagulase negative staphylococcus (CoNS) isolated as sole pathogen AND two clinical signs AND one laboratory parameter OR Pathogen isolated from blood or cerebrospinal fluid culture, not related to infection at another site AND two clinical signs LCBI with non-CoNS pathogen isolated in blood culture or cerebrospinal fluid, and pathogen not related to infections at other site AND two clinical signs Clinical sepsis without proof of pathogen No pathogens isolated from blood or culture not taken Physician prescribes antimicrobials for at least 5 days No apparent infection at another site AND Two clinical signs, without other recognised cause | Fever>38°C or temperature instability (frequent incubator adjustment) or hypothermia<36.5°C Unexplained metabolic acidosis Base Excess > −10 Tachycardia >200 bpm and/or bradycardia <80 bpm New or more frequent apnoeas Recapillarisation time >2 s New hyperglycaemia>140 mg/dL Other signs of infection: Colour (when recapillarisation time not use), apathy, CRP, interleukin, increased oxygen requirement (intubation) or unstable condition | C-Reactive Protein>2.0 mg/dL Thrombocytes<100/nL I/T ratio>0/2 * Leukocytes<5/nL (without erythroblasts) *immature granulocytes/total granulocytes |
| NNAP40 | The growth of a recognised pathogen in pure culture OR in the case of a mixed growth, or growth of skin commensal, the added requirement for 3 or more of 10 predefined clinical signs | Tachypnoea/clinically relevant increase in oxygen or ventilation support Clinically relevant increase in apnoea, bradycardias Hypotension Hypoglycaemia or hyperglycaemia Impaired peripheral perfusion, pallor, mottling, Capillary Refill Time >3 s, toe-core gap>2 Lethargy, irritability, poor handling Temperature instability Ileus, feed intolerance Reduced urine output Metabolic acidosis BE >−10 | N/A |
| CDC41 | An LCBI where central line or umbilical catheter was in place for >2 calendar days on the date of event, with the day of device placement being day 1, AND the line was also in place on the date of event or the day before LCBI: Patient of any age has a recognised pathogen identified AND organism identified in blood is not related to an infection at another site OR Patient<1 year of age has at least one clinical sign AND organism identified from blood is not related to an infection at another site AND the same common commensal is identified from two or more specimens | Fever Hypothermia Apnoea, or bradycardia | N/A |