Table 3

Univariable and adjusted analyses of perinatal infection/inflammation risk factors and between inflammatory and probable asphyxial factors

Univariable analysisMultivariable analysis
Risk factorCase
n (%)
Control
n (%)
Unadjusted
OR
95% CIAdjusted
OR
95% CI
Maternal and newborn C reactive protein (CRP)
Maternal CRP
 <10th centile (≤4.7 mg/L)3/205 (1.5)40/407 (9.8)1.001.00
 10th–90th centile (4.7–86.6 mg/L)131/205 (63.9)327/407 (80.3)5.341.62 to 17.575.211.23 to 22.06
 >90th centile (>86.6 mg/L)71/205 (34.6)40/407 (9.8)23.676.87 to 81.4237.167.86 to 175.66
Neonatal CRP
 <90th centile (<6.6 mg/L)159/205 (77.6)359/398 (90.2)1.001.00
 90th–97th centile (6.6–31.7 mg/L)29/205 (14.2)28/398 (7.0)2.341.35 to 4.063.171.57 to 6.41
 >97th centile (>31.7 mg/L)17/205 (8.3)11/398 (2.8)3.491.60 to 7.629.523.33 to 27.21
Maternal and newborn infection and inflammation
Neonatal bacteraemia*18/210 (8.6)2/105 (1.9)4.831.10 to 21.228.671.51 to 49.74
Histological chorioamnionitis alone (no funisitis)10/60 (16.7)11/102 (10.8)2.330.91 to 5.983.200.66 to 15.52
Histological funisitis (with chorioamnionitis)16/60 (26.7)4/102 (3.9)10.243.19 to 32.8211.802.19 to 63.45
  • *Defined as blood culture and/or species-specific bacterial quantitative Polymerase Chain Reaction (qPCR) for an organism known to be pathogenic among term newborns.

  • †Adjusted for preconception/antepartum factors in table 2, plus intrapartum factors (augmentation of labour, prolonged labour, obstructed labour and acute intrapartum event).