Table 3

Microcephaly and risk of poor birth outcomes before discharge from hospital

Microcephaly (n=794)No microcephaly (n=1 944 010)Prevalence difference per 1000
(95% CI)*
Prevalence ratio
(95% CI)*
Infants, NPrevalence per 1000Infants, NPrevalence per 1000
Mortality5164.2353012.7361.29 (44.37, 78.21)20.52 (15.57, 27.04)
Neonatal intensive care unit 132205.9359 21937.47160.86 (130.28, 191.43)4.80 (4.07, 5.67)
Very preterm, <32 weeks3037.7819 1219.8425.21 (12.64, 37.79)3.19 (2.23, 4.56)
Preterm, <37 weeks202254.41142 19673.15171.43 (141.81, 201.05)3.05 (2.66, 3.50)
Length of stay, ≥7 days174219.1477 78640.01172.69 (144.20, 201.19)4.62 (3.93, 5.43)
Length of stay, ≥14 days105132.2434 92017.96110.24 (87.02, 133.46)5.95 (4.80, 7.38)
Necrotising enterocolitis56.3014960.775.55 (0.03, 11.06)6.59 (2.75, 15.82)
Intracranial haemorrhage1316.3727491.4114.52 (5.73, 23.31)9.90 (5.71, 17.16)
Bronchopulmonary dysplasia810.0826031.348.05 (1.55, 14.55)5.97 (3.01, 11.87)
Intrauterine growth restriction213268.2664 84933.36232.14 (201.29, 262.99)7.21 (6.35, 8.17)
Birth hypoxia95119.65117 23260.3047.46 (27.24, 67.68)1.88 (1.55, 2.27)
C-section175220.40394 103202.7310.43 (−17.84, 38.69)1.05 (0.93, 1.19)
Intubation3949.1214 5067.4638.76 (24.64, 52.88)5.75 (4.20, 7.87)
Transfusion1923.9359753.0718.40 (8.43, 28.38)6.51 (4.15, 10.22)
Phototherapy6986.9073 03337.5746.28 (26.83, 65.74)2.12 (1.67, 2.66)
  • *Models contain microcephaly as the exposure (microcephaly vs no microcephaly) and birth issues as outcomes, and are adjusted for maternal age, parity, multiple birth, rurality, material deprivation and period.

  • †Restricted to 1993–2012, when data were available.