Relationship between OMM and BPD: binary logistic regression models
| Step 1 | Step 2 | |||
|---|---|---|---|---|
| Variable | Adjusted OR (95% CI) | p Value | Adjusted OR (95% CI) | p Value |
| GA per week | 0.429 (0.329 to 0.560) | <0.01 | 0.424 (0.327 to 0.549) | <0.01 |
| Female | 0.474 (0.215 to 1.047) | 0.07 | 0.430 (0.198 to 0.936) | 0.03 |
| NEC | 6.317 (1.852 to 21.550) | <0.01 | 6.740 (2.083 to 21.806) | <0.01 |
| PDA | 3.296 (1.411 to 7.699) | <0.01 | 3.061 (1.338 to 7.002) | <0.01 |
| SGA | 15.115 (4.407 to 51.836) | <0.01 | 13.115 (3.974 to 43.285) | <0.01 |
| HM-PCT per 10% increase | – | – | 0.905 (0.824 to 0.995) | 0.04 |
| Model ROC area under the curve | 0.892 | 0.899 | ||
| Pseudo-R2 (Nagelkerke) | 0.533 | 0.550 | ||
Step 1: BW, GA, SGA at birth, gender, race/ethnicity, chorioamnionitis, antenatal steroids, 5-min Apgar score, maximal support received in delivery room, surfactant, caffeine, respiratory severity score DOL (day of life) 14, sepsis, NEC, PDA, DOL first feeding and DOL 1–7 intravenous fluids entered in the logistic regression model to identify and retain the significant variables with p values <0.1.
Step 2: The five significant variables (GA, gender, NEC, PDA and SGA) and HM-PCT entered in the logistic regression model.
BPD, bronchopulmonary dysplasia; DOL, day of life; GA, gestational age; HM-PCT, human milk dose as a proportion of enteral feedings; NEC, necrotising enterocolitis; OMM, own mother's milk; PDA, patent ductus arteriosus; ROC, receiver operating characteristic; SGA, small for GA at birth.