Intervention | Outcome affected | Risk adjustment |
---|---|---|
Antenatal steroids | IVH (all grades) | RR 0.54 (0.43–0.69)11 |
Developmental delay (3 years) | RR 0.49 (0.24–1.00)11 | |
CP (all severities 2–6 years) | RR 0.60 (0.34–1.03)11 | |
Magnesium sulfate in labour | CP (all severities 12–24 months) | RR 0.68 (0.54–0.87)19 |
CP (severe and moderate 12–24 months) | RR 0.64 (0.44–0.92)19 | |
Gross motor dysfunction (18–24 months) | RR 0.61 (0.44–0.85)19 | |
Deferred cord clamping | IVH (all grades) Gross motor dysfunction (18–22 months) | RR 0.59 (0.41–0.85)20 OR 0.32 (0.10–0.90)21 |
Caffeine | CP (all severities 12–22 months) | AOR 0.58 (0.390.87)22 |
Cognitive delay (18–22 months) | AOR 0.81 (0.66–0.99)22 | |
Prophylactic indomethacin | IVH (Grades 3 and 4) | RR 0.66 (0.53–0.82)23 |
Ventriculomegaly, PVL or other white matter echo-abnormalities | RR 0.80 (0.65–0.97)23 | |
Volume ventilation | PVL and IVH (Grades 3 and 4) | RR 0.48 (0.28–0.84)24 |
AOR, adjusted OR; CP, cerebral palsy; IVH, intraventricular haemorrhage; PVL, periventricular leukomalacia; RR, relative risk.