Morbidity to death or hospital discharge in 22–27 weeks' gestation infants admitted to NICU
| N=445 NICU admissions | Outborn n=49 | Inborn n=396 | Univariable OR (95% CI) | p Value | Adjusted* OR (aOR) (95% CI) | p Value |
|---|---|---|---|---|---|---|
| Any NEC | 6 (12.2%) | 46 (11.6%) | 1.06 (0.43 to 2.63) | 0.90 | 1.21 (0.48 to 3.06) | 0.69 |
| Stage 1 | 3 (6.1%) | 18 (4.5%) | 1.36 (0.38 to 4.79) | 0.64 | 1.39 (0.31 to 5.07) | 0.62 |
| Stage 2 | 2 (4.1%) | 10 (2.5%) | 1.63 (0.35 to 7.68) | 0.54 | 1.98 (0.40 to 9.80) | 0.40 |
| Stage 3 | 1 (2%) | 18 (4.5%) | 0.45 (0.06 to 3.47) | 0.45 | 0.56 (0.07 to 4.37) | 0.56 |
| NEC surgery | 0 | 15 (3.8%) | NC | NC | NC | NC |
| Any IVH | 23 (46.9%) | 138 (34.8%) | 1.65 (0.91 to 3.01) | 0.099 | 1.73 (0.90 to 3.30) | 0.098 |
| Grade 1 or 2 | 13 (27%) | 96 (24%) | 1.40 (0.91 to 2.14) | 0.12 | 1.50 (0.95 to 2.39) | 0.09 |
| Grade 3 or 4 | 10 (20%) | 42 (11%) | 0.92 (0.23 to 3.78) | 0.91 | 0.85 (0.19 to 3.70) | 0.83 |
| PVL | 6 (12.2%) | 11 (2.8%)† | 4.86 (1.71 to 13.79) | 0.003 | 5.34 (1.84 to 15.54) | 0.002 |
| ROP‡ | 16/38 (42%) | 168/322 (52%) | 0.67 (0.34 to 1.32) | 0.24 | 0.88 (0.42 to 1.86) | 0.75 |
| Death or ROP | 27 (55.1%) | 242 (61.1%) | 0.78 (0.43 to 1.42) | 0.42 | 0.96 (0.49 to 1.87) | 0.90 |
| BPD§ | 19/39 (48.7%) | 196/331 (59.2%) | 0.65 (0.34 to 1.27) | 0.21 | 0.99 (0.46 to 2.11) | 0.98 |
| Death or BPD | 29 (59.2%) | 263 (66.4%) | 0.73 (0.40 to 1.34) | 0.32 | 0.99 (0.49 to 2.02) | 0.98 |
| Home in oxygen | 7 (14.3%) | 79 (19.9%) | 0.67 (0.29 to 1.54) | 0.35 | 0.76 (0.32 to 1.80) | 0.53 |
| Mean difference (95% CI) | p Value (t-test) | Adjusted OR (95% CI) | p Value | |||
| Length of stay in days: mean (SD) survivors to D/C n=360 | n=38 95.8 days (25.6) Range 62–149 | n=322 116.1 days (60.3) Range 54–749 | 20.3 days (0.8 to 39.8) | 0.041 | 0.99 (0.98 to 1.00) | 0.19 |
Data are n (%).
*Adjusted for gestational age, birth weight (Z-score) and sex.
†n=2 missing data.
‡ROP reported for 360 survivors to discharge.
§BPD reported for 370 survivors at 36 weeks’ postmenstrual age.
BPD, bronchopulmonary dysplasia; D/C, discharge home; IVH, intraventricular haemorrhage; NC, not calculable; NEC, necrotising entercolitis; NICU, neonatal intensive care unit; PVL, periventricular leukomalacia; ROP, retinopathy of prematurity.