Table 2

Discontinuity values in seconds, MRI, seizure burden and neurodevelopment for the study babies

Baby	DC* 10 μV at 24 h	DC* 15 μV at 24 h	BGT	PLIC	White matter	Seizure burden†	Neurodevelopmental outcome
1	0	0	Mild	Normal	Mild	None	Normal
2	0	0	Mild	Normal	Moderate	None	Normal
3	0	0	Mild	Normal	Moderate	None	Normal
4	0	0	Mild	Normal	Normal	None	Normal
5	0	0	Mild	Normal	Mild	None	Normal
6	0	0	Mild	Normal	Normal	Low	Normal
7	0	0	Normal	Normal	Mild	Low	Normal
8	0	0	Mild	Normal	Mild	None	Normal
9	0	0	Mild	Normal	Moderate	None	Bilateral SN hearing loss
10	0	0	Normal	Normal	Normal	None	n/a
11	0	0	Normal	Normal	Normal	None	n/a
12	0	0.1	Normal	Normal	Normal	None	Normal
13	0	0.2	Mild	Normal	Normal	None	Normal
14	0	0.2	Normal	Normal	Severe	High	Normal
15	0	0.2	Mild	Normal	Moderate	High	Normal
16	0	0.2	Mild	Normal	Moderate	Low	Seizures and unilateral hearing loss
17	0	1.2	Normal	Normal	Mild	None	Normal
18	0	3.3	Moderate	Partially Impaired	Severe	High	Normal
19	0	21.5	Mild	Normal	Moderate	High	Normal
20	0.1	0.8	Moderate	Normal	Severe	High	Mild speech delay
21	0.1	1.8	Mild	Normal	Normal	None	Normal
22	0.1	12.5	Normal	Normal	Normal	None	Normal
23	0.2	1.7	Mild	Normal	Mild	None	n/a
24	0.2	3.3	Mild	Normal	Mild	High	Normal
25	0.3	18.6	Normal	Partially Impaired	Normal	None	Normal
26	0.6	3.5	Moderate	Normal	Mild	None	Normal
27	0.6	9.9	Normal	Normal	Mild	Low	Normal
28	0.9	11.1	Severe	Severely Impaired	Severe	High	Dyskinetic CP
29	1.2	8.6	Normal	Normal	Severe	High	Normal
30	2.4	16	Moderate	Normal	Moderate	None	n/a
31	2.4	18.5	Normal	Normal	Normal	Low	Bilateral SN hearing loss, significant receptive and expressive speech delay
32	2.9	9.4	Mild	Normal	Moderate	None	Normal
33	3.6	9.3	Mild	Normal	Mild	High	Normal
34	4.8	24.3	Normal	Normal	Normal	Low	n/a
35	5	19.6	Mild	Normal	Mild	High	Mild delay
36	7.4	23.3	Mild	Normal	Mild	Low	Normal
37	7.9	18.8	Moderate	Severely Impaired	Mild	None	Normal
38	25.2	47.3	Normal	Normal	Mild	Low	n/a
39	27.7	50.4	Mild	Normal	Mild	High	Normal
40	31.2	43.5	Severe	Severely Impaired	Moderate	Low	Quadriplegic CP
41	47.3	50.3	Moderate	Severely Impaired	Mild	High	Spastic quadriplegic CP, GDD, SN hearing loss and dystonia
42	49.2	54.4	Severe	Severely Impaired	Moderate	High	GDD, microcephaly, visual impairment, dystonia with epilepsy and GORD
43	51.4	56.5	Severe	Severely Impaired	Moderate	High	Quadriplegic CP
44	51.8	56	Severe	Severely Impaired	Severe	Low	Died
45	54.5	58	Moderate	Severely Impaired	Severe	High	Global speech delay, autism and seizures
46	55.3	57.9	Moderate	Severely Impaired	Moderate	High	Died
47	58.6	59.9	Severe	Severely Impaired	Moderate	Low	Died
48	58.9	59.7	Mild	Partially Impaired	Normal	High	Died
49	59.4	59.5	Severe	Severely Impaired	Moderate	High	Spastic quadriplegic CP

*DC: Discontinuity (at stated threshold and time epoch).
†Low seizure burden includes either no or sporadic seizures; high seizure burden includes either frequent seizures or status epilepticus.
BGT, basal ganglia and thalami; CP, cerebral palsy; GDD, global developmental delay; GORD, gastro-oesophageal reflux disease; PLIC, posterior limb of the internal capsule; SN, sensorineural.