Univariable analyses for the association between risk factors and poor outcome on MRI (first grid) and multivariable regression model assessing significant factors in univariable analyses against poor MRI outcome (second grid)
| Univariable analysis | ||
|---|---|---|
| Independent | χ2 or ANOVA* statistic | p Value |
| Seizure burden | 8.76 | 0.003 |
| Apgar 10 | *F=3.13 | 0.084 |
| Lowest cord or infant pH in 1st hour | *F=0.03 | 0.860 |
| Worst base deficit in 1st hour | *F=1.23 | 0.273 |
| Use of anticonvulsants | 2.28 | 0.131 |
| Binary logistic regression | OR | Lower CI | Upper CI | p Value |
|---|---|---|---|---|
| Seizure burden | 4.20 | 1.01 | 17.5 | 0.05 |
| 10 μV at 24 h | 1.05 | 1.01 | 1.1 | 0.01 |
| 15 μV at 24 h | 1.04 | 1.01 | 1.1 | 0.01 |
| 10 μV at 48 h | 1.06 | 1.00 | 1.1 | 0.04 |
| 15 μV at 48 h | 1.05 | 1.01 | 1.1 | 0.01 |
| Predictive values of discontinuity (>30 s) for unfavourable MRI outcomes | ||||||
|---|---|---|---|---|---|---|
| Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Area under ROC | p Value | |
| 10 μV at 24 h | 53 | 94 | 82 | 79 | 0.80 | 0.001 |
| 15 μV at 24 h | 53 | 91 | 75 | 78 | 0.79 | 0.001 |
| 10 μV at 48 h | 41 | 97 | 87 | 76 | 0.78 | <0.001 |
| 15 μV at 48 h | 47 | 94 | 80 | 77 | 0.81 | 0.001 |
| Predictive values of discontinuity (>30 s) for unfavourable neurodevelopmental outcomes | ||||||
|---|---|---|---|---|---|---|
| Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | OR | 95% CI | |
| 10 μV at 24 h | 71 | 100 | 100 | 88 | – | – |
| 15 μV at 24 h | 71 | 97 | 91 | 88 | 9.6 | 1.48 to 62.66 |
| 10 μV at 48 h | 50 | 97 | 87 | 80 | 6.4 | 1.02 to 40.33 |
| 15 μV at 48 h | 64 | 96 | 90 | 85 | 8.5 | 1.31 to 54.78 |
Predictive values for unfavourable outcome with a mean discontinuity >30 s on MRI (third grid) and neurodevelopmental outcome (fourth grid).
ANOVA, analysis of variance; NPV, negative predictive value; PPV, positive predictive value; ROC, receiver operating characteristic.