Table 3

Univariable analyses for the association between risk factors and poor outcome on MRI (first grid) and multivariable regression model assessing significant factors in univariable analyses against poor MRI outcome (second grid)

Univariable analysis
Independentχ2 or ANOVA* statisticp Value
Seizure burden8.760.003
Apgar 10*F=3.130.084
Lowest cord or infant pH in 1st hour*F=0.030.860
Worst base deficit in 1st hour*F=1.230.273
Use of anticonvulsants2.280.131
Binary logistic regressionORLower CIUpper CIp Value
Seizure burden4.201.0117.50.05
10 μV at 24 h1.
15 μV at 24 h1.
10 μV at 48 h1.
15 μV at 48 h1.
Predictive values of discontinuity (>30 s) for unfavourable MRI outcomes
Sensitivity (%)Specificity (%)PPV (%)NPV (%)Area under ROCp Value
10 μV at 24 h539482790.800.001
15 μV at 24 h539175780.790.001
10 μV at 48 h419787760.78<0.001
15 μV at 48 h479480770.810.001
Predictive values of discontinuity (>30 s) for unfavourable neurodevelopmental outcomes
Sensitivity (%)Specificity (%)PPV (%)NPV (%)OR95% CI
10 μV at 24 h7110010088
15 μV at 24 h719791889.61.48 to 62.66
10 μV at 48 h509787806.41.02 to 40.33
15 μV at 48 h649690858.51.31 to 54.78
  • Predictive values for unfavourable outcome with a mean discontinuity >30 s on MRI (third grid) and neurodevelopmental outcome (fourth grid).

  • ANOVA, analysis of variance; NPV, negative predictive value; PPV, positive predictive value; ROC, receiver operating characteristic.