Univariable analysis | ||
---|---|---|

Independent | χ^{2} or ANOVA* statistic | p Value |

Seizure burden | 8.76 | 0.003 |

Apgar 10 | *F=3.13 | 0.084 |

Lowest cord or infant pH in 1st hour | *F=0.03 | 0.860 |

Worst base deficit in 1st hour | *F=1.23 | 0.273 |

Use of anticonvulsants | 2.28 | 0.131 |

Binary logistic regression | OR | Lower CI | Upper CI | p Value |
---|---|---|---|---|

Seizure burden | 4.20 | 1.01 | 17.5 | 0.05 |

10 μV at 24 h | 1.05 | 1.01 | 1.1 | 0.01 |

15 μV at 24 h | 1.04 | 1.01 | 1.1 | 0.01 |

10 μV at 48 h | 1.06 | 1.00 | 1.1 | 0.04 |

15 μV at 48 h | 1.05 | 1.01 | 1.1 | 0.01 |

Predictive values of discontinuity (>30 s) for unfavourable MRI outcomes | ||||||
---|---|---|---|---|---|---|

Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Area under ROC | p Value | |

10 μV at 24 h | 53 | 94 | 82 | 79 | 0.80 | 0.001 |

15 μV at 24 h | 53 | 91 | 75 | 78 | 0.79 | 0.001 |

10 μV at 48 h | 41 | 97 | 87 | 76 | 0.78 | <0.001 |

15 μV at 48 h | 47 | 94 | 80 | 77 | 0.81 | 0.001 |

Predictive values of discontinuity (>30 s) for unfavourable neurodevelopmental outcomes | ||||||
---|---|---|---|---|---|---|

Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | OR | 95% CI | |

10 μV at 24 h | 71 | 100 | 100 | 88 | – | – |

15 μV at 24 h | 71 | 97 | 91 | 88 | 9.6 | 1.48 to 62.66 |

10 μV at 48 h | 50 | 97 | 87 | 80 | 6.4 | 1.02 to 40.33 |

15 μV at 48 h | 64 | 96 | 90 | 85 | 8.5 | 1.31 to 54.78 |

Predictive values for unfavourable outcome with a mean discontinuity >30 s on MRI (third grid) and neurodevelopmental outcome (fourth grid).

ANOVA, analysis of variance; NPV, negative predictive value; PPV, positive predictive value; ROC, receiver operating characteristic.