Perinatal characteristics (total neonates=49) | |
---|---|
Male sex | 32 (65%) |
Median birth weight, grams (range) | 3360 (2450–4560) |
Median Apgar score at 10 min (IQR), n=44 | 6 (4, 8) |
Median first pH, by cord or within 1 h, (IQR), n=48 | 6.91 (6.81, 7.10) |
Median first base deficit, by cord or within 1 h, mmol/L (IQR), n=46 | −16.9 (−11.3, −21.5) |
Need for respiratory support at 10 min age | 37 (76%) |
Median age when heart rate first >100/min, minutes (IQR), n=48 | 2 (1, 5) |
Median age at first gasp, minutes (range) n=41 | 5 (0, 20) |
Antenatal sentinel event identified | 8 (16%) |
Suspected clinical seizures | 36 (73%) |
Treated with anticonvulsants | 37 (76%) |
Received sedation during cooling | 42/46 (91%) |
Median age at start of aEEG monitoring (range), n=47 | 4 h 50 m (15 m to 11 h 20 m) |
Median duration of aEEG monitoring (range), n=48 | 89 h 53 m (13 h 20 m to 168 h 58 m) |
Any seizures identified on aEEG/EEG | 29 (59%) |
High seizure burden on aEEG/EEG | 18 (37%) |
Epoch analysed at 24 h and 48 h, minutes (range) | 119 (80, 120) |
Median age at MRI, days (IQR) | 11 (8, 14) |
Severe pattern of injury on MRI (group 1) | 17/49 (35%) |
Unfavourable neurodevelopmental outcome | 14/43 (33%) |
aEEG, amplitude-integrated electroencephalographic (EEG).