Table 1

Characteristics of study infants

Perinatal characteristics (total neonates=49)
Male sex32 (65%)
Median birth weight, grams (range)3360 (2450–4560)
Median Apgar score at 10 min (IQR), n=446 (4, 8)
Median first pH, by cord or within 1 h, (IQR), n=486.91 (6.81, 7.10)
Median first base deficit, by cord or within 1 h, mmol/L (IQR), n=46−16.9 (−11.3, −21.5)
Need for respiratory support at 10 min age37 (76%)
Median age when heart rate first >100/min, minutes (IQR), n=482 (1, 5)
Median age at first gasp, minutes (range) n=415 (0, 20)
Antenatal sentinel event identified8 (16%)
Suspected clinical seizures36 (73%)
Treated with anticonvulsants37 (76%)
Received sedation during cooling42/46 (91%)
Median age at start of aEEG monitoring (range), n=474 h 50 m (15 m to 11 h 20 m)
Median duration of aEEG monitoring (range), n=4889 h 53 m (13 h 20 m to 168 h 58 m)
Any seizures identified on aEEG/EEG29 (59%)
High seizure burden on aEEG/EEG18 (37%)
Epoch analysed at 24 h and 48 h, minutes (range)119 (80, 120)
Median age at MRI, days (IQR)11 (8, 14)
Severe pattern of injury on MRI (group 1)17/49 (35%)
Unfavourable neurodevelopmental outcome14/43 (33%)
  • aEEG, amplitude-integrated electroencephalographic (EEG).