Table 1

Published clinical studies about NHFOV in neonates

Author/yearSample sizeType of studyPatients' conditionType of patientsInterfaceGenerating systemMain results
van der Hoeven/19983521Case seriesRDS, TTN, AOP, air leaksTerm and pretermNasopharyngeal tubeFlow-interruption↓PaCO2
Hoehn/2000361Case reportRDSExtremely pretermNasopharyngeal tubeFlow-interruption↓PaCO2 avoid one reintubation
Colaizy/20083814Non-randomised crossover trialRDS in recovery phaseTerm and pretermNasopharyngeal tubeFlow-interruptionNHFOV is safe ↓PaCO2
Czernik/20124020Case seriesDifficult extubation after various types of respiratory failureTerm and pretermNasopharyngeal tubePiston/membraneSuggested usefulness for high-risk extubation
Aktas/2014373Case seriesRDS or developing BPDExtremely pretermNasal prongsFlow-interruptionNHFOV is safe and feasible
Mukerji/2014652Case seriesBPD spells, postextubation, others unspecifiedTerm and pretermNasal prongs/maskPiston/membrane or flow-interruptionLess spells
Neonates (total)111 
  • Searched in PubMed with NHFOV [All Fields] or non [All Fields] AND invasive [All Fields] AND HFOV [All Fields]. The search was also conducted in Pediatric Academic Societies abstracts archive (2002–2014) and authors’ personal archives (as per 7 February 2016).

  • Studies are listed in order of publication.

  • AOP, apnoea of the prematurity; BPD, bronchopulmonary dysplasia; NHFOV, non-invasive high-frequency oscillatory ventilation; RDS, respiratory distress syndrome; TTN, transient tachypnoea of the neonate.