Table 3

Summary of ongoing randomised clinical trials about NHFOV in neonates

CountryStatus (cause)PatientsControl armPrimary outcomeSecondary outcomesIdentifier
ChinaNot yet recruiting>28 weeks; postextubationNIPPVIntubation rateApnoea, air leaks, BPD, NEC incidenceNCT02543125
CanadaSuspended (poor recruitment)<28 weeks; postextubationCPAPIntubation ratePaCO2, air leaks, IVH, feeding intoleranceNCT01852916
GermanyRecruiting<32 weeks; postextubationCPAPPaCO2Other gas exchange measures, intubation rate, IVH, BPD, NECNCT02340299
CanadaRecruiting<1250 g; >72 hours of life; failing postextubation CPAPBiPAPFailure of NHFOV/BiPAPIntubation rate, ventilation length, PaCO2, NICU stay, IVH, BPD, apnoeic spells, common adverse outcomesNCT02051491
  • Search has been conducted using ‘NHFOV’ or ‘HFOV’ and ‘non-invasive’ or ‘NHFIV’ as keywords in, IRSCTN Registry and in the Australian-New Zealand Clinical Trials Registry (as per 7 February 2015). All trials have been registered only in

  • BiPAP, biphasic positive airway pressure; BPD, bronchopulmonary dysplasia; CPAP, continuous positive airway pressure; IVH, intraventricular haemorrhage; NEC, necrotising enterocolitis; NHFOV, non-invasive high-frequency oscillatory ventilation; NICU, neonatal intensive care unit; NIPPV, non-invasive positive pressure ventilation.