Effect of indomethacin prophylaxis timing (≤6 h of age) on intraventricular haemorrhage (IVH) or death
| Clinical outcomes | Adjusted OR (95% CI)* |
|---|---|
| Total IVH (any grade) | 1.00 (0.84 to 1.19) |
| Total IVH or death | 0.95 (0.82 to 1.13) |
| Severe IVH (grade 3/4) | 1.03 (0.84 to 1.27) |
| Severe IVH or death | 1.01 (0.85 to 1.20) |
*Multivariable analyses adjusted for the following covariates: network centre, gestational age, maternal hypertension, maternal antibiotics, antenatal steroids, caesarean section, race, male sex, small for gestational age, chest compressions in delivery room, outborn, patent ductus arteriosus and admission temperature. ORs <1 in the multivariable logistic regression favoured the <6 h group, hence the reference was the >6–24 h group.