Effect of indomethacin prophylaxis timing (≤6 h of age) on patent ductus arteriosus (PDA) or death
| Clinical outcomes | Adjusted OR (95% CI)* |
|---|---|
| PDA | 0.88 (0.74 to 1.05) |
| PDA or death | 0.88 (0.75 to 1.04) |
| PDA receiving treatment/ligation | 0.81 (0.67 to 0.98) |
| PDA receiving treatment/ligation or death | 0.83 (0.71 to 0.98) |
*Multivariable analysis to adjust for the following covariates: network centre, gestational age, maternal hypertension, maternal antibiotics, antenatal steroids, caesarean section, race, male gender, small for gestational age, chest compressions in delivery room, outborn and admission temperature. ORs <1 in the multivariable logistic regression favoured the <6 h group, hence the reference was the >6–24 h group.