Neonatal characteristics of study cohort
| Features* | Time of indomethacin | p Value | |
|---|---|---|---|
| ≤6 h (n=2340) | >6–24 h (n=1915) | ||
| Gestational age (weeks) | 25+5/7 | 25+4/7 | 0.19 |
| Birth weight (g) | 747±148 | 741±145 | 0.16 |
| Male | 1150 (49%) | 927 (48%) | 0.64 |
| Admission temperature | 36.1±1.1 | 35.8±1.1 | <0.0001 |
| Race (whites) | 1303 (56%) | 995 (52%) | 0.05 |
| Outborn | 73 (3%) | 278 (15%) | <0.0001 |
| Respiratory support (24 h)† | 2255 (97%) | 1875 (98%) | <0.01 |
| Use of surfactant | 2028 (86%) | 1701 (89%) | 0.04 |
| Pneumothorax | 161 (7%) | 132 (7%) | 1.00 |
| Early-onset sepsis | 43 (2%) | 48 (<3%) | 0.14 |
*Values represent either the mean±SD or proportions expressed as a percentage.
†Any invasive or non-invasive positive pressure ventilation.