Inhospital variables and outcomes for infants based on receipt of antihypotensive therapy and rise in blood pressure
| Untreated expected BP rise (n=91) | Untreated less than expected BP rise (n=67) | Treated expected BP rise (n=128) | Treated less than expected BP rise (n=70) | p Value | |
|---|---|---|---|---|---|
| Birth weight (g), mean±SD | 784±165 | 750±144 | 692±150 | 713±168 | <0.001 |
| GA at birth (weeks), mean±SD | 25.5±0.9 | 25.6±1.0 | 25.1±1.1 | 25.3±1.0 | <0.001 |
| Antenatal corticosteroids, n (%) | 81 (89) | 61 (91) | 118 (92) | 65 (93) | 0.814 |
| Any severity of illness marker, n (%) | 37 (41) | 37 (55) | 93 (73) | 56 (80) | <0.001 |
| 1 min Apgar score ≤3 | 33 (36) | 33 (49) | 79 (62) | 49 (70) | <0.001 |
| DR chest compressions | 5 (5) | 7 (10) | 14 (11) | 8 (11) | 0.5 |
| Positive initial blood culture | 0 | 0 | 3 (2) | 5 (7) | 0.01 |
| Any pH <7.10 in the first 24 h | 1 (1) | 3 (4) | 13 (10) | 11 (16) | 0.003 |
| First haematocrit <30% | 4 (4) | 3 (4) | 25 (20) | 12 (17) | <0.001 |
| Severe IVH or PVL, n (%) | 11 (12) | 8 (13) | 28 (23) | 21 (31) | 0.008 |
| NEC requiring surgery, n (%) | 4 (5) | 2 (4) | 6 (7) | 2 (4) | 0.881* |
| Intervention for ROP, n (%) | 9 (12) | 6 (11) | 18 (20) | 14 (27) | 0.071 |
| BPD, n (%) | 40 (51) | 36 (63) | 58 (62) | 34 (62) | 0.402 |
| Survival to hospital discharge | 77 (85) | 54 (81) | 89 (70) | 52 (74) | 0.055 |
*Fisher's exact test.
BP, blood pressure; BPD, bronchopulmonary dysplasia; DR, delivery room; GA, gestational age; IVH, intraventricular haemorrhage; NEC, necrotising enterocolitis; PVL, periventricular leukomalacia; ROP, retinopathy of prematurity.