Table 2

Outcomes at 18–22 months for infants based on receipt of antihypotensive therapy and rise in BP

Untreated expected BP rise (n=91)Untreated less than expected BP rise (n=67)Treated expected BP rise (n=128)Treated less than expected BP rise (n=70)p Value
Death or any ND impairment/delay, n (%)24 (26)19 (28)58 (45)33 (47)0.002
Any ND impairment/delay, n (%)*9 (14)6 (12)16 (23)14 (30)0.079
Language composite score, mean±SD86±1687±1384±1783±180.531
Cognitive composite score, mean±SD91±1490±1086±1788±170.33
Motor composite score, mean±SD89±1589±1286±1786±180.53
Language composite score <70, n (%)*8 (12)2 (4)13 (19)9 (19)0.081
Cognitive composite score <70, n (%)*5 (8)1 (2)11 (16)7 (15)0.0554
Motor composite score <70, n (%)*7 (11)4 (8)10 (14)10 (21)0.162
GMFCS level ≥2, n (%)*4 (6)4 (8)9 (13)8 (17)0.251
Blindness, n (%)*1 (2)0000.697†
Deafness, n (%)*1 (2)1 (2)1 (1)3 (6)0.426†
  • *Denominator is infants who had a neurodevelopmental assessment at 18–22 months’ corrected age.

  • †Fisher's exact test.

  • BP, blood pressure; GMFCS, Gross Motor Function Classification System; ND, neurodevelopment.