Outcomes
| Outcome | Flow driver (n=59) | Bubble (n=66) | Effect* | 95% CI | ||
|---|---|---|---|---|---|---|
| CPAP days, GM† | 0.48 | 0.35 to 0.65 | 0.65 | 0.46 to 0.91 | 1.3 | 0.9 to 2.1 |
| CPAP plus supplementary oxygen days, GM† | 1.67 | 1.14 to 2.45 | 1.98 | 1.33 to 2.93 | 1.2 | 0.7 to 1.9 |
| Necrotising enterocolitis, n % | 1 | 2% | 0 | 0% | – | |
| Retinopathy of prematurity, n % | 0 | 0% | 0 | 0% | – | |
| Periventricular leucomalacia, n % | 0 | 0% | 2 | 3% | – | |
| Periventricular haemorrhage, n % | 2 | 3% | 5 | 8% | 2.1 | 0.4 to 12.7 |
| Death, n % | 1 | 2% | 3 | 5% | 2.3 | 0.2 to 27.8 |
| Ventilation, n % | 3 | 5% | 7 | 11% | 2.1 | 0.5 to 9.3 |
| Nasal excoriation, n % | 2 | 3% | 3 | 5% | 1.2 | 0.2 to 8.0 |
| Pneumothorax, n % | 1 | 2% | 3 | 5% | 2.4 | 0.2 to 26.2 |
*ORs for binary outcomes, adjusted for gestational age; ratio for log-transformed continuous outcomes, adjusted for gestational age, sex and antenatal steroids.
†GM and 95% CI, for survivors.
CPAP, continuous positive airway pressure; GM, geometric mean.