Behaviour scores from the Strengths and Difficulties Questionnaire for children exposed to GM-CSF compared with control children in the PROGRAMS trial groups at 5 years
| GM-CSF | Control | Difference in medians (95% CI) | |
|---|---|---|---|
| Median (IQR) | |||
| Parent SDQ | (n=62) | (n=54) | |
| Emotional disorder score (max. 15) | 6 (6, 7) | 6 (5, 7) | 0 (0 to 1) |
| Disorder n (%) | 0 (0%) | 0 (0%) | |
| Conduct disorder score (max 15) | 5 (5, 5) | 5 (5, 6) | 0 (0 to 0) |
| Disorder n (%) | 0 (0%) | 1 (2%) | |
| Hyperactivity disorder score (max 15) | 5 (4, 6) | 5 (4, 6) | 0 (0 to 1) |
| Disorder n (%) | 40 (65%) | 38 (70%) | |
| Peer relationships score (max 15) | 5 (5, 7) | 5 (5, 7) | 0 (0 to 0) |
| Disorder n (%) | 1 (2%) | 2 (4%) | |
| Overall score (max 60) | 23 (20, 25) | 21 (19, 24) | 1.0 (−0.3 to 2.2) |
| Disorder n (%) | 0 (0%) | 0 (0%) | |
| Teacher SDQ | (n=73) | (n=70) | |
| Emotional disorder score (max. 15) | 6 (5, 7) | 6 (5, 8) | 0 (0 to 0) |
| Disorder n (%) | 0 (0%) | 0 (0%) | |
| Conduct disorder score (max 15) | 5 (4, 5) | 5 (5, 5) | 0 (0 to 0) |
| Disorder n (%) | 0 (0%) | 0 (0%) | |
| Hyperactivity disorder score (max. 15) | 5 (4, 6) | 5 (4, 6) | 0 (-1 to 0) |
| Disorder n (%) | 40 (55%) | 34 (49%) | |
| Peer relationships score (max 15) | 5 (4, 5) | 5 (4, 5) | 0 (0 to 0) |
| Disorder n (%) | 10 (14%) | 2 (3%) | |
| Overall score (max 60) | 21 (19 to 23) | 21 (20 to 23) | −0.5 (−1.4 to 0.5) |
| Disorder n (%) | 0 (0%) | 0 (0%) | |
| School adaptation (impact) | 3 (2, 4) | 3 (2, 4) | 0 (0 to 1) |
‘Disorder’ indicates the number of children with borderline or clinical scores compared with reference data.
GM-CSF, granulocyte macrophage colony stimulating factor; SDQ, Strengths and Difficulties Questionnaire.