Variables | All patients (n=43) | No injury (n=17) | Injury (n=26) | p Value |
---|---|---|---|---|
Clinical characteristics | ||||
Gestational age (weeks), mean±SD | 39.19±1.51 | 39.38±1.39 | 39.07±1.59 | 0.57 |
Birth weight (g), mean±SD | 3310±502 | 3368±520 | 3271±497 | 0.47 |
Sex | 0.92 | |||
Male, n (%) | 30 (70) | 12 (71) | 18 (69) | |
Female, n (%) | 13 (30) | 5 (29) | 8 (31) | |
Apgar score ≤5 at 10 min, n (%) | 26 (60) | 10 (59) | 16 (62) | 0.86 |
Intubation at birth, n (%) | 37 (86) | 14 (82) | 23 (88) | 0.57 |
Chest compression at birth, n (%) | 22 (51) | 11 (65) | 11 (42) | 0.15 |
Arterial cord pH, mean±SD | 6.99±0.18 | 6.96±0.17 | 7.01±0.20 | 0.45 |
Initial postnatal blood gas pH, mean±SD | 7.05±0.16 | 7.05±0.15 | 7.06±0.17 | 0.99 |
Initial amplitude-integrated encephalogram background | 0.01 | |||
Moderate encephalopathy, n (%) | 23 (53) | 13 (76) | 10 (38) | |
Severe encephalopathy, n (%) | 20 (47) | 4 (24) | 16 (62) | |
Initiation of hypothermia (hours), mean±SD | 5.08±1.32 | 4.96±1.46 | 5.16±1.23 | 0.38 |
The initial background pattern of the amplitude-integrated EEG was assessed on admission and categorised into moderate or severe encephalopathy.2 ,21
Each MRI was scored using a previously described MRI scoring system,23 which permitted the classification of the patients into basal ganglia injury (BG), watershed injury (W) and total brain injury (cortical grey matter (CGM)+WM+BG).