Table 2

Screening, diagnostic and clinical assessment results on infants identified with cCMV

Case	Saliva (screening sample) CMV PCR	Urine CMV PCR*	Dried blood spot (DBS) CMV PCR	Blood CMV PCR (copies/mL)*	Infant serology*	Clinical assessment (birthweight, head circumference, clinical examination)	Hearing	Eye exam	Blood count and liver function	Cranial imaging	Treated
1	Positive day 15	Negative day 17 Positive day 43	Negative	Not tested	IgM positive IgG low avidity Day 43	Normal	Normal	Normal	Normal	USS: Normal MRI: Normal	No
2	Positive day 1	Positive day 11	Negative	Not detected	Not done	Normal	Normal	Normal	Normal	USS: Normal	No
3	Positive day 6	Positive day 23	Positive	3.1×10⁴ day 23	Not done	Normal	Profound unilateral SNHL	Normal	Normal	USS: subependymal cysts	Valganciclovir 6 weeks
4	Positive day 0	Positive day 8	Negative	<2×10³ day 8	Not done	Normal	Normal	Normal	Normal	USS: Normal	No
5	Positive day 0	Positive day 13	Negative	7.7×10³ day 13	Not done	Normal	Profound unilateral SNHL	Normal	Normal	USS: subependymal cysts	Valganciclovir 6 weeks
6	Positive day 3	Positive day 10	Positive	1.2×10⁴ day 10	Not done	Small for Gestational Age (2nd centile)	Moderate unilateral SNHL	Normal	Normal	USS: subependymal cysts MRI: normal	Valganciclovir 6 weeks

*Where samples taken by local PID team. Bold typeface indicates where abnormal clinical finding identified.
cCMV, congenital cytomegalovirus; PID, Paediatric Infectious Diseases; SNHL, sensorineural hearing loss; USS, ultrasound scan.