Table 1

Perinatal characteristics (total subjects=85)

Male sex, n57 (67%)
Median birth weight, grams (range)3360 (2042–5300)
Median Apgar score at 10 min (IQR)5 (4, 7)
Median first pH, by cord or within 1 h (IQR)6.90 (6.78, 6.97)
Median first base deficit, by cord or within 1 h, mmol/L (IQR)−18.5 (−15.0, −23.0)
Need for respiratory support at 10 min age, n70 (82%)
Median age when heart rate first >100/min, minutes (IQR)2 (1, 5)
Median age at first gasp, minutes (range)5 (0, 95)
Antenatal sentinel event identified, n21 (25%)
Suspected clinical seizures, n58 (68%)
Treated with anticonvulsants, n*60 (72%)
Received sedation during cooling, n†74/81 (91%)
Median age at start of aEEG monitoring (range)5 h 12 min (15 min to 11 h 20)
Median duration of aEEG monitoring (range)93 h 55 (6 h 55 to 174 h 57)
Any seizures identified on aEEG/EEG, n44 (52%)
High seizure burden on aEEG/EEG, n30 (35%)
Burst suppression, continuous low voltage or flat trace in the first 24 h42 (49%)
Burst suppression, continuous low voltage or flat trace at 48 h of age‡14 (17%)
Median age at MRI, days (range)9 (4, 35)
Severe pattern of injury on MRI (group 1), n 31 (36%)
Survived to discharge home or to local hospital, n80 (94%)
  • *Data unavailable for 2 subjects.

  • †Data unavailable for 4 subjects.

  • ‡3 subjects did not have aEEG data at 48 h.