Crude bivariate analyses for association between risk factors and severe MRI outcome (upper grid) and multivariate regression model assessing the effect of factors significant in bivariate analyses on MRI outcomes (lower grid)
| Independent | Pearson χ2 or ANOVA* statistic | p Value |
|---|---|---|
| Seizures (yes/no) | 12.86 | <0.001 |
| Seizure burden (high or low) | 18.25 | <0.001 |
| Burst suppression, continuous low voltage or flat trace in first 24 h | 15.31 | <0.001 |
| Burst suppression, continuous low voltage or flat trace at 48 h age | 13.89 | 0.001 |
| Cord or first pH within 1 h | *F=1.15 | 0.29 |
| Cord or first base excess within 1 h | *F=2.29 | 0.09 |
| Apgar at 10 min | *F=15.91 | <0.001 |
| Use of anticonvulsants | 4.52 | 0.10 |
| Infants needing more than one anticonvulsant compared with those needing one | 6.79 | 0.009 |
| Age at MRI | *F=1.29 | 0.22 |
| Multivariate regression model assessing the effect of factors significant in above bivariate analyses on MRI outcomes | ||||
|---|---|---|---|---|
| Factor | OR | 95% CI | p Value | |
| Lower | Upper | |||
| Seizure burden | 5.00 | 1.47 | 17.05 | 0.01 |
| Apgar at 10 min | 0.80 | 0.59 | 1.10 | 0.18 |
| Abnormal aEEG background in first 24 h | 2.30 | 0.50 | 10.51 | 0.28 |
| aEEG background at 48 h | 2.55 | 0.48 | 13.54 | 0.27 |
*ANOVA, analysis of variance.