Incidences of IH in preterm infants reported in the literature
| Study (Ref.) | Survey period/source | Age range covered for IH occurrence | Target population | N infants included | IH incidence N (%) | Comment |
|---|---|---|---|---|---|---|
| Holmdahl23 | 1951–1954 hospital based | Birth to 20 weeks | BW ≤2000 g BW 2010–2500 BW ≥2500 | 293 347 186 | 20 (6.8) 16 (4.6) 15 (8.1) | Inconsistencies in text and tables. Results potentially questionable. |
| Powell et al24 | 1980–1981 Epidemiologic, regional based, retrospective, registers and charts | Survivors, birth to 1 year | BW ≤2000 g GA 25–29 wk GA 30–34 wk GA 35+ wk | 615 85 300 230 | 68 (11.1) 16 (18.8) 33 (11.0) 19 (8.3) | Incidence increases with decreasing GA, p=0.015 Boys vs girls: 9% vs 13% p=0.02 No selection bias |
| Amir et al25 | 1977–1984 retrospective hospital based charts and clinic reports | Survivors, birth to 1 year | BW <2000 g BW 500–1000 g BW 1001–1500 BW 1501–2000 | 973 96 418 459 | 78 (12.7) 22 (22.9) 58 (13.9) 44 (9.6) | Male to female ratio 1:1.4. Frequency increases with decreasing BW |
| Queisser-Luft et al26 | 1990–1991 Register of congenital Malformations | First 10 days | All newborns | 8332 | 225 (2.7) | Type of haemangioma and GA or BW not indicated |
| Haggstrom et al19 | Sept 2002–Oct 2003 | Not defined | Infants referred to seven paediatric dermatology clinics <12 years | 1058 to compare with US National Vital Statistics System | Infants with IH more likely: female p<0.00 001; white p<0.0001; preterm/very preterm p<0.0001; LBW/VLBW p<0.0001; to have mother >30 years | |
| Garzon et al22 | Sept 2002–Oct 2003 Prospective. Practices based | Not defined | Infants referred to seven paediatric dermatology practices | 833 term; 214 preterm | Female to male ratio 2.62; female to male ratio 1.85 p=0.04; mean no. of IH/patients: term vsGA<32 wk=1.4:1.8 p<0.001 IH in face: less in preterms p<0.005. Relevant referral bias | |
| Drolet BA24 | Sept 2002–Oct 2003 Prospective | Not defined | Infants referred to two paediatric hospitals | 420 IH; 353 controls | Infant with IH are more likely to be preterm p<0.0001; female p<0.0001; LBW p<0.0001; white p<0.0001. Every 500 g decrease=IH increase by 40%. Relevant referral bias | |
| Praveen et al27 | 2000–2005 Retrospective evaluation of neonatal database | Birth to discharge | BW ≤1250 g | 351 | 49 (14) | Recruitment stopped at discharge |
| Dickison et al28 | 2007–2011 Prospective. Hospital based | Birth to 24 wk | Newborns with maternal consent | 1065; term 933; pret 132 | 19 (2.0) 9 (6.8) | Female to male ratio 5:1; not all infants <32 wk included. Relevant recruitment bias |
| Kanada et al20 | Not reported; hospital based; prospective | Birth to 3 m | All newborns | 594 term; 523 pret 71 | 22 (4.3) 7 (9.8) | Relevant recruitment bias |
| Doege et al29 | 1999–2005 hospital based charts; retrospective | During neonatal period | GA <37 wk GA 23–26 GA 27–30 GA 31–34 GA 35–36 | 2563 155 346 1038 1024 | 110 (4.3) 24 (15) 41 (12) 40 (4) 5 (0.5) | Result potentially underestimating true incidence: incomplete chart documentation, recruitment stopped at discharge |
BW, birth weight; GA, gestational age; IH, infantile haemangioma; pret, preterm; (V)LBW, (very) low birth weight; vs, versus; wk, weeks.