Table 5

Antibiotic resistance of the main Gram-negative organisms causing early-onset and late-onset neonatal sepsis in four Asian centres

BacteriaUnit†CR n/N (%)GR n/N (%)CRGR n/N (%)Total infected
Klebsiella spp.KTM41/69 (59)29/69 (42)27/69 (39)71
HYHT16/23 (70)17/22 (77)15/22 (68)25
CHHP15/24 (63)4/20 (20)3/20 (15)24
Total72/116 (62)50/111 (45)***45/111 (41)**120
E coliKTM7/23 (30)6/24 (25)3/23 (13)24
HYHT8/13 (62)8/13 (62)7/13 (54)14
CHHP6/16 (38)8/16 (50)4/16 (25)16
Total21/52 (40)22/53 (42)14/52 (27)*54
Acinetobacter spp.KTM0/3 (00)0/4 (00)0/3 (00)6
HYHT9/13 (69)9/12 (75)8/12 (67)13
CHHP6/8 (75)4/8 (50)4/8 (50)8
Total15/24 (63)13/24 (54)12/23 (52)27
Enterobacter spp.KTM3/13 (23)1/13 (08)1/13 (08)13
HYHT5/8 (63)5/8 (63)4/8 (50)8
CHHP2/3 (67)1/3 (33)1/3 (33)3
Total10/24 (42)7/24 (29)*6/24 (43)24
Pseudomonas spp.KTM3/17 (18)3/25 (12)3/17 (18)27
HYHT0/1 (00)0/1 (00)0/1 (00)1
CHHP3/6 (50)2/6 (33)1/6 (17)6
Total6/24 (25)5/32 (16)4/24 (17)34
Serratia spp.KTM1/15 (07)1/15 (07)1/15 (07)17
HYHT0/0 (00)0/0 (–)0/0 (–)0
CHHP2/4 (50)0/4 (00)0/4 (00)4
Total3/19 (16)1/19 (05)1/19 (05)21
TotalKTM55/140 (39)40/150 (27)35/140 (25)158
HYHT38/58 (66)39/56 (70)34/56 (61)61
CHHP34/61 (56)19/57 (33)13/57 (23)61
Total127/269 (47)*98/263 (37)***82/253 (32)***280
  • *p<0.05; **p<0.01; ***p<0.001.

  • Out of seven Gram-negative infections in Centro Hospitalar Conde de Sao Januario-Macau, five were tested for sensitivity and four of which were E coli. Out of four E coli one was resistant to Cephalosporin and three were resistant to gentamicin.

  • CHHP, Children's Hospital of Hebei Province; HYHT, Hat Yai Hospital in Thailand; KTM, Kuala Terengganu in Malasia.