Outcomes of infants with a large patent ductus arteriosus (PDA) randomised to indomethacin or placebo
| Indomethacin | Placebo | p Value | |
|---|---|---|---|
| N | 44 | 48 | |
| Primary outcome (death/abnormal cranial ultrasound) | 8 (18%) | 9 (19%) | 1.0 |
| Died | 4 (9%) | 5 (10%) | 1.0 |
| PIVH Grade 2–4 | 2 (4.5%) | 6 (12.5%) | 0.21 |
| PVL/Cysts/Dilation | 4 (9%) | 4 (8%) | 1.0 |
| GA stratification primary outcome | |||
| 23–24 weeks | 3/8 | 3/8 | 1.0 |
| 25–26 weeks | 3/15 | 5/16 | 0.69 |
| 27–28 weeks | 2/21 | 1/24 | 0.59 |
GA, gestational age; PIVH, periventricular/intraventricular haemorrhage; PVL, periventricular leukomalacia.