Table 2

Detection of cyanosis in specific congenital heart anomalies by pulse oximetry screening—published birth cohorts 1998–2009

KoppelReichRosatiArlettazReichBakrKawalecde Wahl GranelliMebergSendelbachRiedeEwerPrudhoe*Total95%CI
Birth cohort1998–992000–012000–042003–042003–0520042004–052004–072005–62006–072006–082008–091999–091998–09
Screened (n)112812114529232627962521127200398215000815233414452005529925258809
Timing>24 h>24 h>24 h<24 h>24 h>24 hAt∼24 h>24 h<24 h<24 h>24 h<&>24 h<24 h
ProbesSingleSingleSingleSingleSingleTwinSingleTwinSingleSingleSingleTwinSingle
Trigger threshold<96%<95%<95%<95%<95%<95% (†)<95%<95% (>3%)<95%<96%<96%<95% (>2%)<95%
Single vent1/12/21/12/26/661 to 100%
HLHS3/32/22/23/33/51/15/51/120/2272 to 97%
Tricuspid Atr1/11/13/45/644 to 97%
Truncus1/12/23/31/11/12/310/1162 to 98%
DORV3/31/11/15/557 to 100%
TGA1/12/26/611/128/84/57/86/745/4981 to 97%
PA+IVS1/11/11/13/344 to 100%
PA+VSD1/11/12/23/32/22/21/15/617/1874 to 99%
AVSD1/28/91/22/412/1747 to 87%
TAPVC2/21/21/11/11/14‡/52/25/51/12‡/220‡/2270 to 97%
Fallot2/30/36/82/41/10§11/2824 to 58%
CoA/IAA0/11/21/10/23/44‡/133‡/61/43/72/1018/5024 to 50%
Ao arch hypoplasia1/21/29 to 90%
Ao Atr/ St1/13/44/538 to 96%
PS1/30/11/11‡/11/11/55/1219 to 68%
  • *Data from Richmond et al5 is contained within the current study report.

  • †Pre- and postductal measurements taken, with action demanded if either below 95%. No specified action on percentage difference.

  • ‡Indicates that some of these cases were discharged undiagnosed despite low saturation in the first 24 h of life.

  • §Includes three cases of tetralogy in term babies diagnosed in the first year of life, but not receiving surgery until the second year of life.

  • Diagnostic categories follow the hierarchy used by Fyler et al.28

  • Italics indicates diagnoses considered primary targets for pulse oximetry screening by Kemper et al.12

  • Ao arch hypoplasia, aortic arch hypoplasia; Ao Atr/St, aortic valve atresia or stenosis; AVSD, atrioventricular septal defect; CoA/IAA, coarctation of the aorta or interrupted aortic arch; DORV, double-outlet right ventricle; Fallot, Fallot's tetralogy; HLHS, hypoplastic left heart syndrome; PA+IVS, pulmonary atresia with intact ventricular septum; PA+VSD, pulmonary atresia with ventricular septal defect; PS, pulmonary stenosis; Single vent, single ventricle; TAPVC, total anomalous pulmonary venous connection; TGA, transposition of the great arteries; Tricuspid Atr, tricuspid atresia; Truncus, truncus arteriosus.