18-h CRP distribution according to GA (<35 and ≥35 weeks), EOS diagnosis (proven, possible, or not infected) and the composite variable ‘symptomatic or not’
| EOS | |||||
|---|---|---|---|---|---|
| GA | CRP (mg/L) | Symptomatic | Proven | Possible | Not infected |
| <35 weeks | |||||
| <10 | |||||
| No | 0 | 3 | 138 | ||
| Yes | 0 | 37 | 200 | ||
| ≥10 | |||||
| No | 1 | 3 | 57 | ||
| Yes | 12 | 45 | 150 | ||
| Unknown* | 1 | ||||
| ≥35 weeks | |||||
| <10 | |||||
| No | 0 | 1 | 188 | ||
| Yes | 1 | 2 | 75 | ||
| ≥10 | |||||
| No | 0 | 1 | 149 | ||
| Yes | 2 | 15 | 120 | ||
| Unknown* | 1 | ||||
A neonate was considered symptomatic if he/she has at least one of the following symptoms within the first 18 h of life: respiratory distress lasting for more than 3 h after birth, haemodynamic instability treated with volemic expansion and/or inotropic agents, lethargy, or feeding intolerance.
*There were two infants for which the status ‘symptomatic’ was unknown.
CRP, C-reactive protein; EOS, early onset sepsis; GA, gestational age.