Table 2

Individual characteristics of non-cooled neonates with hypoxia-ischaemic encephalopathy

								Second-line anticonvulsant
Case	Clinical Sarnat	Recorded seizure burden (min)	Seizure number (n)	Mean seizure duration (s)	Age at first EEG seizure	Age at first-line anticonvulsant	Time from EEG seizure onset to treatment	Age	Total dose	Other drugs
C1^S	2	38	4	574	10 h 15 m	N	N			M
C2	3	106	43	147	18 h			23 h 14 m	Pt=10 mg/kg	M
C3^S	2	116	21	331	26 h 11 m	8 h 5 m	B	25 h 5 m	Pt=20 mg/kg
C4^S	3	137	84	98	14 h 12 m	N	N			M, Tr
C5^S	2	152	99	92	22 h 30 m	22 h 34 m	4 m	32 h 44 m	Pt=20 mg/kg
C6^{E, S}	2	172	21	493	25 h 30 m	19 h 13 m	B	28 h 28 m	Pt=20 mg/kg
C7^E	3	183	121	91	12 h 40 m	12 h 20 m	B	35 h 35 m	Mz=100 mcg/kg	M
C8^E	3	199	41	291	17 h 7 m	10 h 50 m	B			M
C9	3	206	60	206	12 h 20 m	24 h 24 m	12 h 4 m			M
C10^{E, S}	2	212	66	193	10 h 54 m	10 h 10 m	B	28 h 40 m	Pt=20 mg/kg
C11	3	239	150	96	10 h 56 m	19 h 35 m	8 h 39 m
C12^E	3	384	209	110	21 h 58 m	2 h 30 m	B		Pt=20 mg/kg	Cn, M
C13^{E, S}	2	413	63	393	17 h 54 m	10 h 3 m	B
C14^{E, S}	3	640	305	126	16 h 48 m	18 h 13 m	1 h 25 m	29 h 13 m	Pt=20 mg/kg	Pr, Mz, Py
C15^E	3	958	190	303	27 h 28 m	6 h 34 m	B	9 h 44 m	Pt=5 mg/kg	Mz, Py
C16^E	3	1002	201	299	20 h 35 m	16 h 37 m	B	26 h 47 m	Pt=40 mg/kg	M, D

B, clinically treated before EEG commenced; C, neonates enrolled from the Cork University Maternity Hospital; Cn, clonazepam; D, intravenous diazepam; E, neonates with status epilepticus; M, morphine; Mz, midazolam; N, not given any anticonvulsant; Pr, paraldehyde; Pt, phenytoin; Py, pyridoxine; S, neonates who were already seizing at the time when EEG was commenced; Tr, trichloral hydrate.