MRI findings among study subjects by region and pattern of injury
| MRI results | Hypothermia group, n=73 (%) | Control group, n=63 (%) | p Value |
|---|---|---|---|
| Normal | 38 (52) | 22 (35) | 0.06 |
| Abnormal | 35 (48) | 41 (65) | |
| Total hemispheric devastation | |||
| Any | 2 (3) | 6 (10) | 0.14 |
| L=R (5) | 2 | 5 | |
| L>R (4) | 0 | 1 | |
| Cerebral lesions, n (%) | 30 (41) | 35 (56) | 0.12 |
| Any frontal | 25 (83) | 25 (71) | |
| Any temporal | 21 (70) | 25 (71) | |
| Any parietal | 23 (77) | 26 (74) | |
| Any occipital | 19 (63) | 24 (69) | |
| BGT classification, n (%)* | 0.21 | ||
| Normal | 48 (69) | 30 (51) | |
| Minimal | 5 (7) | 5 (8) | |
| Moderate | 8 (11) | 11 (19) | |
| Severe | 9 (13) | 13 (22) | |
| PLIC classification, n (%)* | 0.06 | ||
| Normal | 46 (64) | 28 (45) | |
| Equivocal | 13 (18) | 13 (21) | |
| Abnormal | 13 (18) | 21 (34) | |
| ALIC classification, n (%)* | 0.05 | ||
| Normal | 46 (63.9) | 28 (45.2) | |
| Equivocal | 14 (19.4) | 13 (21.0) | |
| Abnormal | 12 (16.7) | 21 (33.9) | |
| Watershed area | 0.02 | ||
| 0=no infarction | 64 (88) | 48 (77) | |
| 1=single focal infarction | 0 (0) | 0 (0) | |
| 2=anterior or posterior WM | 2 (3) | 0 (0) | |
| 3=anterior, posterior watershed cortex and WM | 1 (1) | 2 (3) | |
| 4=anterior and posterior watershed | 2 (3) | 0 (0) | |
| 5=more extensive cortical involvement beyond watershed zones | 4 (5) | 12 (19) | |
| Pattern of injury | |||
| Barkovich | 0.053 | ||
| 0 | 46 (64.8) | 27 (43.6) | |
| 1 | 14 (19.7) | 12 (19.4) | |
| 2 | 2 (2.8) | 4 (6.5) | |
| 3 | 7 (9.9) | 12 (19.4) | |
| 4 | 2 (2.8) | 7 (11.3) | |
| Rutherford | 0.10 | ||
| a | 39 (58.2) | 23 (38.3) | |
| b | 5 (7.5) | 2 (3.3) | |
| c | 4 (6.0) | 3 (5.0) | |
| d | 5 (7.5) | 7 (11.7) | |
| e | 3 (4.5) | 6 (10.0) | |
| f | 1 (1.5) | 5 (8.3) | |
| g | 7 (10.5) | 13 (21.7) | |
| h | 3 (4.5) | 1 (1.7) | |
| NICHD NRN | 0.15 | ||
| 0 | 38 (52.1) | 22 (34.9) | |
| 1A | 4 (5.5) | 2 (3.2) | |
| 1B | 1 (1.4) | 3 (4.8) | |
| 2A | 5 (6.9) | 3 (4.8) | |
| 2B | 23 (31.5) | 27 (42.9) | |
| 3 | 2 (2.7) | 6 (9.5) | |
↵* BGT, seven infants could not be classified; PLIC, two infants could not be classified; ALIC, two infants could not be classified; areas of infarction, one infant could not be classified.
Barkovich: 0=normal, 1=abnormal BGT, 2=abnormal signal in cortex, 3=abnormal cortex and BGT, 4=abnormal entire cortex and BGT. Three infants could not be classified using this pattern.
Rutherford: a=normal; b=minimal BGT with or without cortical involvement; c=moderate WM with or without cortical involvement; d=moderate BGT, with or without cortical involvement and PLIC equivocal or abnormal; e=moderate WM and BGT; f=multifocal WM, with or without cortical involvement, with normal BGT and PLIC; g=severe BGT with focal WM and cortex, and abnormal PLIC; and h=severe BGT, abnormal PLIC, abnormal WM and cortex. Nine infants could not be classified using this pattern.
ALIC, anterior limb of the internal capsule; BGT, basal ganglia and thalamic area; NICHD NRN, National Institute of Child Health and Human Development Neonatal Research Network; PLIC, posterior limb of the internal capsule; WM, white matter.