Table 2

Key neonatal interventions and potential mechanisms of action

Mechanism:Intervention
Modulating effect via:PrebioticsProbioticsLactoferrinAntibiotics
A: direct effect of exposure on other mediatorsXX
B: direct effect of exposure on microbiota?
C: direct effect of exposure on diseaseXXXX
D: interaction between microbiota and other mediatorsX
E: direct effect of microbiota on disease?
F: direct effect of immunotype on diseaseXX?X