Authors | Infant urinary iodine | Infant TSH levels | Infant T4 or FT4 levels | Diagnosis of transient hypothyroidism* | Comment |
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Parravicini et al22 | Mean postnatal day 3 4000 µg/L exposed 100 µg/L non-exposed day 7 1800 µg/L exposed 400 µg/L non-exposed | Mean TSH on postnatal day 1 10 µU/mL exposed 8 µU/mL non-exposed day 7 18 µU/mL exposed 2.5 µU/mL non-exposed | Mean FT4 on postnatal day 1 0.9 ng/dL exposed 1.0 ng/dL non-exposed day 7 1.1 ng/dL exposed 0.9 ng/dL non-exposed | 3/9 exposed 33 per 100 0/18 non-exposed 0 per 100 |
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Smerdely et al4 | Median postnatal day 3 1100 µg/L exposed 70 µg/L non-exposed day 7 750 µg/L exposed 60 µg/L non-exposed | Median TSH on postnatal day 3 4.0 mIU/L exposed 2.5 mIU/L non-exposed day 7 4.5 mIU/L exposed 2.5 mIU/L non-exposed | Median T4 on postnatal day 3 55 nmol/L exposed 72 nmol/L non-exposed day 7 58 nmol/L exposed 62 nmol/L non-exposed | 9/36 exposed 25 per 100 (8/9 on thyroxine replacement) 0/27 non-exposed 0 per 100 |
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Linder et al24 Inter NICU | Not reported | Mean TSH on postnatal day 10 15.4±19.2 mIU/L exposed 10/73 TSH >30 mIU/L 7.8±5 mIU/L non-exposed 0/55 TSH >30 mIU/L | Mean T4 on postnatal day 10 8.4±2.7 µg/dL exposed 9/73 had T4 <5 µg/dL 7.8±2.6 µg/dL non-exposed 6/55 had T4 <5 µg/dL | 10/73 exposed 14 per 100 0/55 non-exposed 0 per 100 |
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Linder et al24 Intra NICU | On day of exposure 2115 to 18 900 µg/L exposed 55 to 100 µg/L non-exposed | Mean TSH at postnatal day 7 12 mIU/L exposed 10 mIU/L non-exposed day 45 19 mIU/L exposed 7 mIU/L non-exposed | Mean T4 at postnatal day 7 6.5 µg/dL exposed 14 µg/dL non-exposed day 45 8 µg/dL exposed 8.5 µg/dL non-exposed | 5/24 exposed 21 per 100 0/22 non-exposed 0 per 100 |
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Brown et al23 | Mean postnatal day 1 3610 µg/L exposed 148 µg/L non-exposed day 3 1780 µg/L exposed 87 µg/L non-exposed | Mean TSH at postnatal day 1 <20 mU/L exposed <20 mU/L non-exposed day 4–6 <20 mU/L exposed <20 mU/L non-exposed | Mean T4 postnatal day 1 69±14 nmol/L exposed 68±13 nmol/L non-exposed day 4–6 64±31 nmol/L exposed 72±14 nmol/L non-exposed | 2/17 exposed 12 per 100 0/14 non-exposed 0 per 100 |
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AvRuskin et al25 | Not recorded | Mean TSH pre-exposure 1.3±0.5 mIU/L Mean TSH postexposure 0.3±0.2 mIU/L | Mean T4 pre-exposure 6.4±1.0 ng/dL Mean T4 postexposure 4.1±0.6 ng/dL Mean FT4 pre-exposure 0.7±0.1 µg/dL Mean FT4 postexposure 0.8±0.1 µg/dL | 0/9 exposed |
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Casteels et al21 | 3932 µg/L | TSH day 5, <1 µU/mL TSH day 23, 23 µU/mL TSH day 29, 287.9 µU/mL | FT4 day 29, 0.28 ng/dL | 1/1 exposed |
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Jeng et al26 | Not recorded | Mean levels TSH pre-exposure 5 mU/L TSH 12 h postexposure 7 mU/L TSH 48 h postexposure 8 mU/L TSH 120 h postexposure 12 mU/L | Mean levels T4 pre-exposure 5 µg/dL T4 12 h postexposure 4.8 µg/dL T4 48 h postexposure 4.8 µg/dL T4 120 h postexposure 4.8 µg/dL | 1/6 exposed |
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Khashu et al27 | day 38, 833 µg/L day 44, 805 µg/L day 76, 105 µg/L | TSH day 34, 455 mU/L TSH day 39, >500 mU/L TSH day 44, 6.4 mU/L TSH day 51, 3.85 mU/L TSH day 59, 1.5 mU/L TSH day 74, 2.6 mU/L | FT4 day 34, 0.51 ng/dL FT4 day 39, 0.60 ng/dL FT4 day 44, 1.75 ng/dL FT4 day 51, 1.32 ng/dL FT4 day 59, 1.31 ng/dL FT4 day 74, 1.28 ng/dL | 1/1 exposed |
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Müther et al28 | Not reported | TSH twin 1 day 6 postnatal 271 µE/mL twin 2 324 µE/mL twin 1 week 4 postnatal 0.57 µE/mL Twin 2 1.62 µE/mL | T4 twin 1 day 6 postnatal 3.28 µg/dL twin 2 2.56 µg/dL twin 1 week 4 postnatal 11.2 µg/dL Twin 2 10.9 µg/dL | 2/2 exposed |
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Smith et al29 | 684 µg/L | TSH Day 4, 16.8 µU/mL Day 14, 45 µU/mL Day 21, 77 µU/mL | T4 Day 4, 8.4 mcg/dL Day 14, 6.3 mcg/dL Day 21, 4.5 mcg/dL | 1/1 exposed |
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Bona et al30 | 1860 µg/L and 400 µg/L day 3–5 postnatal | TSH 200 µU/mL and 190 µU/mL | Not reported | 2/2 exposed |
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Llinares et al31 | Not reported | TSH 104 µU/mL | T4 4 g/dL | 1/1 exposed |
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Malpuech et al32 | Not reported | TSH >16 ng/100 mL TSH 14.6 ng/100 mL | 1.3 µg/100 mL 2.2 µg/100 mL | 2/2 exposed |
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Ryan et al33 | Presurgery Mean 2.55±2.3 µmol/L 24 h postsurgery 160±105.9 µmol/L 14 days postsurgery 1.5±0.8 µmol/L | Presurgery Mean TSH 3.6±1.6 U/L 24 h postsurgery 2 U/L 14 days postsurgery 4±1.6 U/L | Presurgery Mean T4 112±27 µmol/L 24 h postsurgery 90±33 µmol/L 14 days postsurgery 112±11 µmol/L | 0/4 exposed |
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Conversion to SI units FT4 ng/dL×12.87=pmol/L.
*Includes hyperthyrotropinaemia.