GM-CSF (n−=−100) | Control (n=101) | ||
---|---|---|---|
Outcome | n/total (%) | n/total (%) | RR 95% CI |
Chest symptoms | |||
Cough | |||
>once a week | 10 (10) | 16 (16) | |
Weekly–monthly | 12 (12) | 0 (0) | |
Once a month or less | 30 (30) | 30 (30) | |
Cough without infection | 36 (36) | 22 (22) | 1·7 (1·1 to 2·6) |
Wheeze | |||
>once a week | 5 (5) | 6 (6) | |
Weekly–monthly | 5 (5) | 5 (5) | |
Once a month or less | 22 (22) | 19 (19) | |
Wheeze without infection | 28 (28) | 20 (20) | 1·4 (0·9 to 2·3) |
Chest medicines | |||
Bronchodilators during last 12 months | 22 (22) | 26 (26) | 0·9 (0·5 to 1·4) |
Inhaled steroids during last 12 months | 12 (12) | 10 (10) | 1·2 (0·5 to 2·8) |
Supplemental oxygen at discharge | 16/98 (16) | 23 (23) | 0·7 (0·4 to 1·3) |
Supplemental oxygen at 2 years | 1 (1) | 2 (2) | 0·5 (0·0 to 5·5) |
Respiratory examination | |||
Tracheostomy | 0/95 (0) | 1/98 (1) | – |
Chest deformity | 20/92 (22) | 10/90 (11) | 2·0 (1·0 to 3·9) |
Harrison's sulcus | 19/92 (21) | 10/90 (11) | |
Hyperinflation | 9/92 (10) | 1/90 (1) | |
Hospital admissions | |||
Respiratory admission (n) | 35 (35) | 37 (37) | 1·0 (0·7 to 1·4) |
Median no. (upper quartile; max)* | 2 (3; 8) | 1 (2; 4) | |
Surgical admission (n) | 18 (19) | 22 (22) | 0·8 (0·5 to 1·5) |
Median no. (upper quartile; max)* | 1 (1; 2) | 1 (2; 4) | |
ICU admission and ventilated (n) | 3 (3) | 5 (5) | 0·6 (0·2 to 2·5) |
Median no. (upper quartile; max)* | 1 (1; 1) | 1 (1·5; 2) | |
Admission other reason (n) | 10/55 (18) | 8/59 (14) | 1·3 (0·6 to 3·1) |
Median no. (upper quartile; max)* | 1 (1; 2) | 1 (2; 4) |
↵* Median number of admissions among those who had an admission.
GM-CSF, granulocyte-macrophage colony-stimulating factor; ICU, intensive care unit.