Table 4

PROGRAMS: respiratory and hospital readmission outcomes from discharge from inpatient neonatal care through to 2 years of age corrected for prematurity. The denominator indicates the number of children for whom questionnaires were returned

GM-CSF (n−=−100)Control (n=101)
Outcomen/total (%)n/total (%)RR 95% CI
Chest symptoms
Cough
 >once a week10 (10)16 (16)
 Weekly–monthly12 (12)0 (0)
 Once a month or less30 (30)30 (30)
Cough without infection36 (36)22 (22)1·7 (1·1 to 2·6)
Wheeze
 >once a week5 (5)6 (6)
 Weekly–monthly5 (5)5 (5)
 Once a month or less22 (22)19 (19)
Wheeze without infection28 (28)20 (20)1·4 (0·9 to 2·3)
Chest medicines
 Bronchodilators during last 12 months22 (22)26 (26)0·9 (0·5 to 1·4)
 Inhaled steroids during last 12 months12 (12)10 (10)1·2 (0·5 to 2·8)
 Supplemental oxygen at discharge16/98 (16)23 (23)0·7 (0·4 to 1·3)
 Supplemental oxygen at 2 years1 (1)2 (2)0·5 (0·0 to 5·5)
Respiratory examination
 Tracheostomy0/95 (0)1/98 (1)
 Chest deformity20/92 (22)10/90 (11)2·0 (1·0 to 3·9)
  Harrison's sulcus19/92 (21)10/90 (11)
  Hyperinflation9/92 (10)1/90 (1)
Hospital admissions
Respiratory admission (n)35 (35)37 (37)1·0 (0·7 to 1·4)
Median no. (upper quartile; max)*2 (3; 8)1 (2; 4)
Surgical admission (n)18 (19)22 (22)0·8 (0·5 to 1·5)
Median no. (upper quartile; max)*1 (1; 2)1 (2; 4)
ICU admission and ventilated (n)3 (3)5 (5)0·6 (0·2 to 2·5)
Median no. (upper quartile; max)*1 (1; 1)1 (1·5; 2)
Admission other reason (n)10/55 (18)8/59 (14)1·3 (0·6 to 3·1)
Median no. (upper quartile; max)*1 (1; 2)1 (2; 4)
  • * Median number of admissions among those who had an admission.

  • GM-CSF, granulocyte-macrophage colony-stimulating factor; ICU, intensive care unit.