Table 3

Comparison of subjects with TANEC and subjects with NEC without association to transfusion (non-TANEC)

CharacteristicsTANEC N=144Non-TANEC N=783p Value
Gestational age in weeks, mean (SD)25.8 (2.6)29.3 (3.9)<0.01
Birth weight (kg), mean (SD)0.885 (0.406)1.373 (0.735)<0.01
5-Min Apgar score <7, n (%)67 (46.9)185 (24.1)<0.01
SNAP II score >20, n (%)75 (52.1)179 (22.9)<0.01
Day of life for NEC, median (IQR)20 (12.5–33)14 (8–27)<0.01
PDA, n (%)98 (72.6)249 (32.4)<0.01
PDA needing surgery, n (%)44 (45.8)92 (38.7)0.23
Mortality, n (%)34 (34.0)157 (20.1)<0.01
Severe ROP (stage 3 or higher), n (%)28 (31.1)61 (15.4)<0.01
Severe neurological injury*, n (%)43 (31.9)110 (17.6)<0.01
  • * Defined as Grade 3 or 4 intraventricular haemorrhage or periventricular leukomalacia.

  • NEC, necrotising enterocolitis; PDA, patent ductus arteriosus; ROP, retinopathy of prematurity; SNAP, Score for Neonatal Acute Physiology; TANEC, transfusion-associated NEC.