Details of MIST procedure
| 25–28 Weeks (n=38) | 29–32 Weeks (n=23) | |
|---|---|---|
| Age at which MIST was performed (h) | 3.1 (1.1–4.2) | 9.9 (3.6–17) |
| Two or more catheterisation attempts | 6 (16%) | 6 (26%) |
| Surfactant dose (mg/kg) | 118 (102–166)* | 100 (98–104) |
| Surfactant reflux | 13 (34%) | 5 (22%) |
| Bradycardia >10 s | 15 (39%) | 7 (30%) |
| Positive pressure inflations | 17 (45%) | 7 (30%) |
| Time to restore CPAP (min) | 1.9 (1.0–2.6) | 1.3 (0.84–2.0) |
Median (IQR) or n (%).
↵* 31 infants received a surfactant dose of 100 mg/kg (median dose 106 mg/kg) and seven infants received a dose of 200 mg/kg (median dose of 199 mg/kg).
CPAP, continuous positive airway pressure; MIST, minimally-invasive surfactant therapy.