Table 3

Organisms causing late-onset neonatal sepsis (≥3 days of birth) in four Asian centres, 2006–2009

OrganismKT-MalaysiaHYH-ThailandCHHP-ChinaCHCSJ-MacauTotal
n (%)n (%)n (%)n (%)
Gram-positive
Coagulase-negative staphylococci*80 (25.8)28 (23.0)220 (65.5)2 (14.3)330 (42.2)
 Enterococcus faecalis3 (1.0)10 (8.2)10 (3.0)0 (0.0)23 (2.9)
 Staphylococcus aureus
  MSSA12 (3.9)0 (0.0)13 (3.9)0 (0.0)25 (3.2)
  MRSA16 (5.2)3 (2.5)0 (0.0)0 (0.0)19 (2.4)
 Group B Streptococcus3 (1.0)1 (0.8)0 (0.0)4 (28.6)8 (1.0)
 Other Gram-positive bacteria6 (1.9)4 (3.3)21 (6.2)0 (0.0)31 (4.0)
Gram-negative
 Klebsiella spp.69 (22.3)23 (18.5)24 (7.1)0 (0.0)116 (14.8)
 Escherichia coli 24 (7.7)11 (9.0)12 (3.6)4 (28.6)51 (6.5)
 Acinetobacter spp.5 (1.6)11 (9.0)5 (1.5)1 (7.1)22 (2.8)
 Pseudomonas spp.25 (8.1)1 (0.8)6 (1.8)0 (0.0)32 (4.1)
 Serratia spp.16 (5.2)0 (0.0)4 (1.2)0 (0.0)20 (2.6)
 Enterobacter spp.13 (4.2)7 (5.7)3 (0.9)1 (7.1)24 (3.1)
 Other Gram-negative bacteria†‡12 (3.9)5 (2.5)6 (1.8)0 (0.0)23 (2.9)
 Candida spp.23 (7.4)18 (14.8)0 (0.0)1 (7.1)42 (5.4)
 Other§3 (1.0)0 (0.0)12 (3.6)1 (7.1)16 (2.0)
 Total310 (100)122 (100)336 (100)14 (100)782 (100)
  • *74 (92.5%) in KT-Malaysia and 30 (13.6%) in CHHP-China are methicillin resistant.

  • †Including one case of salmonella in CHHP-China.

  • ‡Including five Flavobacterium spp. in KT-Malaysia and two Flavobacterium spp. in HYH-Thailand.

  • §Two cases of Cryptococcus spp. and one case of Rhodoturula glutinis in KT-Malaysia and one case of Cryptococcus spp. in CHCSJ-Macau.

  • MRSA, methicillin-resistant S aureus; MSSA, methicillin-sensitive Staphylococcus aureus.