Characteristics of seizure burden in non-cooled and cooled groups
| All neonates | Non-cooled (n=16) | Cooled (n=15) | p Value |
|---|---|---|---|
| Recorded seizure burden (min) | 203 (141–406) | 60 (39–224) | 0.027 |
| Total seizure numbers per neonate | 75 (42–180) | 41 (12–161) | 0.105 |
| Mean seizure duration (s) per neonate | 200 (101–324) | 142 (85–274) | 0.192 |
| Number of neonates with status epilepticus | 9 | 4 | 0.095* |
| Age onset of EEG (h) | 15 (5-20) | 6 (3-9) | 0.006 |
| Total EEG duration (h) | 55 (41–60) | 88 (75–101) | 0.001 |
| Moderate HIE | Non-cooled (n=6) | Cooled (n=8) | p Value |
| Recorded seizure burden (min) | 162 (97–262) | 49 (26–89) | 0.020 |
| Total seizure numbers per neonate | 42 (17–74) | 15(3-40) | 0.174 |
| Mean seizure duration (s) per neonate | 362 (168–513) | 258 (87–759) | 0.519 |
| Severe HIE | Non-cooled (n=10) | Cooled (n=7) | p Value |
| Recorded seizure burden (min) | 223 (172–720) | 224 (60–289) | 0.558 |
| Total seizure numbers per neonate | 136 (56–203) | 161 (41–185) | 0.591 |
| Mean seizure duration (s) per neonate | 137 (98–293) | 108 (79–168) | 0.172 |
Data are median (IQR) or n.
↵* χ2 test for the proportion of neonates with status epilepticus in non-cooled and cooled groups.