Period | Preintervention period | 151 | 160 | <0.001 |
Postintervention period | 87 | 197 |
Days preintervention period | Day 1 | 2 | 18 | 0.001 |
Day 2 | 11 | 18 |
Day 3 | 19 | 11 |
Day 4 | 27 | 15 |
Day 5 | 18 | 17 |
Day 6 | 22 | 22 |
Day 7 | 15 | 7 |
Day 8 | 16 | 14 |
Day 9 | 12 | 22 |
Day 10 | 9 | 16 |
Days postintervention period | Day 1 | 6 | 6 | 0.120 |
Day 2 | 10 | 21 |
Day 3 | 11 | 30 |
Day 4 | 8 | 15 |
Day 5 | 3 | 23 |
Day 6 | 10 | 18 |
Day 7 | 13 | 13 |
Day 8 | 10 | 20 |
Day 9 | 9 | 23 |
Day 10 | 7 | 28 |
Observers in preintervention period | Observer 1 | 91 | 80 | 0.069 |
Observer 2 | 60 | 80 |
Observers in postintervention period | Observer 3 | 49 | 116 | 0.687 |
Observer 4 | 38 | 81 |
Preparation | 1: One step: withdrawal of required amount from already prepared stock solution | 111 | 105 | <0.001 |
2: Multiple step: Preparation of stock solution and withdrawal of required amount | 53 | 24 |
3: Multiple step: withdrawal of required amount from stock solution/ampoule and dilution | 24 | 39 |
4: Multiple step: preparation of stock solution, withdrawal of required amount and dilution | 6 | 4 |
5: One step: withdrawal of required amount from ready-to-use preparation (multiple use) | 26 | 175 |
6: One step: withdrawal from ready-to- use ampoule (single use) | 18 | 10 |
Administration | Intravenous bolus | 160 | 37 | <0.001 |
Infusion | 54 | 163 |
Oral, rectal, pulmonal | 24 | 157 |