Relationship between the NICHD MRI pattern of injury and primary outcome within the two groups
| NICHD pattern of injury | Hypothermia group, n=73 | Control group, n=63 |
|---|---|---|
| Death or disability | p<0.0001 | p<0.0001 |
| 0 | 3 (7.9) | 2 (10.0) |
| 1A | 0 (0.0) | 0 (0.0) |
| 1B | 0 (0.0) | 1 (33.3) |
| 2A | 1 (20.0) | 2 (66.7) |
| 2B | 16 (69.6) | 19 (70.4) |
| 3 | 2 (100.0) | 6 (100.0) |
| Death | p=0.37 | p=0.10 |
| 0 | 2 (5.3) | 0 (0.0) |
| 1 | 0 (0.0) | 0 (0.0) |
| 1B | 0 (0.0) | 0 (0.0) |
| 2A | 0 (0.0) | 1 (33.3) |
| 2B | 5 (21.7) | 5 (18.5) |
| 3 | 0 (0.0) | 2 (33.3) |
| Rate of disability | p<0.0001 | p<0.0001 |
| 0 | 1 (2.8) | 2 (10.0) |
| 1A | 0 (0.0) | 0 (0.0) |
| 1B | 0 (0.0) | 1 (33.3) |
| 2A | 1 (20.0) | 1 (50.0) |
| 2B | 11 (61.1) | 14 (63.6) |
| 3 | 2 (100.0) | 4 (100.0) |
The two infants with normal MRI examination died after neonatal intensive care unit discharge: one infant died with viral pneumonia and the cause of death is missing for the other infant.
NICHD, National Institute of Child Health and Human Development.