Individual characteristics of cooled neonates with hypoxia-ischaemic encephalopathy enrolled for this study
| Second-line | anticonvulsant | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Case | Clinical Sarnat | Recorded seizure burden (min) | Seizure number (n) | Mean seizure duration (s) | Age at first EEG seizure | Age at first-line anticonvulsant | Time from EEG seizure onset to treatment | Age | Total dose | Other drugs | Cooling duration (age in h) |
| L1A | 2 | 19 | 4 | 283 | 10 h 59 m | 11 h 30 m | 31 m | M | 72 (12–84) | ||
| L2A | 2 | 24 | 17 | 85 | 11 h 20 m | 12 h 25 m | 1 h 5 m | 26 h | Pt=20 mg/kg | M, Mz | 72 (8–90) |
| L3E | 2 | 31 | 2 | 917 | 6 h 58 m | 7 h 25 m | 27 m | M | 72 (6–78) | ||
| C17 | 3 | 39 | 14 | 168 | 12 h 22 m | 6 h 10 m | B | M | 72 (0.25–72.25) | ||
| L4 | 2 | 48 | 12 | 241 | 24 h 23 m | 31 h 44 m | 7 h 21 m | M | 72 (6–78) | ||
| L5R, A | 2 | 49 | 46 | 64 | 39 h 26 m | 24 h 23 m | B | M | 72 (9–81) | ||
| C18E | 2 | 55 | 2 | 1658 | 8 h 17 m | 9 h 55 m | 1 h 38 m | M | 72 (2–74) | ||
| L6W | 3 | 60 | 41 | 88 | 12 h | 12 h 51 m | 51 m | 20 h 11 m | Mz=150 mcg/kg | M | 33 (0.5–33.5) |
| C19 | 2 | 100 | 22 | 274 | 13 h 25 m | 15 h 38 m | 2 h 13 m | M | 72 (2–74) | ||
| C20 | 2 | 118 | 76 | 93 | 21 h 28 m | 7 h 20 m | B | M | 72 (3–75) | ||
| C21E, W | 3 | 214 | 56 | 229 | 16 h 33 m | 17 h 3 m | 30 m | 28 h 33 m | Pt=20 mg/kg | M | 65 (0.8–66) |
| L7R, W | 3 | 224 | 281 | 48 | 12 h 51 m | 21 h 22 m | 8 h 31 m | 25 h 52 m | Mz=340 mcg/kg | M | 23 (5-28) |
| C22R | 3 | 244 | 185 | 79 | 42 h 13 m | 56 h 25 m | 14 h 12 m | 65 h 35 m | Pt=20 mg/kg | M | 72 (6–78) |
| L8E, R, W | 3 | 289 | 161 | 108 | 13 h 5 m | 27 h 23 m | 14 h 18 m | M | 19 (5-24) | ||
| L9S, W | 3 | 421 | 178 | 142 | 10 h 24 m | 13 h 35 m | 3 h 11 m | 13 h 55 m | Mz=330 mcg/kg | M | 66 (5–71) |
A, documented age onset of active cooling, passive cooling initiated earlier during transport; B, clinically treated before EEG commenced; C, neonates enrolled from Cork University Maternity Hospital; E, neonates with status epilepticus; L, neonates enrolled from University College London Hospital; M, morphine; Mz, midazolam; R, neonates with EEG seizures following discontinuation of cooling; Pt, phenytoin; S, neonates who were already seizing at the time when EEG record was commenced; W, shorter cooling period as part of withdrawal of life-sustaining support decision.