ORs and 95% CIs obtained with time-oriented risk models of chronic lung disease for three patterns of respiratory disease (Low FiO2, PD or EPPD) during the first 4 postnatal weeks
| Low FiO2 | PD | EPPD | |
|---|---|---|---|
| Antenatal | |||
| GA 23–24 weeks | 3.2 (2.0 to 8.8) | 2.5 (1.5 to 4.3) | |
| GA 25–26 weeks | 1.9 (1.1 to 3.1) | ||
| BW z score <−1 | 26 (7.0 to 95) | 4.4 (2.3 to 8.2) | 2.0 (1.1 to 3.9) |
| Male | 1.9 (1.2 to 3.1) | ||
| Caesarean delivery | 0.5 (0.2 to 1.2) | ||
| Indication is PE or FI | 1.9 (0.98 to 3.8) | ||
| Early neonatal (week 1) | |||
| SNAP-II 30+ | 3.3 (1.02 to 11) | 2.0 (1.1 to 3.9) | |
| Definite bactaeremia | 2.6 (1.01 to 6.9) | ||
| Surfactant | 0.2 (0.1 to 0.7) | ||
| Mechanical ventilation on day 7 | 1.5 (0.5 to 3.9) | 4.2 (2.5 to 6.9) | 2.7 (1.5 to 4.7) |
| Late neonatal (weeks 2–4) | |||
| Dexamethasone | 3.0 (1.2 to 7.2) | ||
| Analgesic | 3.4 (1.2 to 9.5) | ||
| PTX | 1.9 (1.1 to 3.2) | ||
| PIE | 17 (2.1 to 140) | 2.6 (1.5 to 4.6) | |
Variables offered are as follows. Antenatal epoch: gestational age 23–24 weeks, gestational age 25–26 weeks, BW z score, sex, complete course of antenatal steroids, multiple birth, caesarean delivery, delivery for preeclampsia or fetal indication, thrombosis of the fetal stem vessels in the placenta. Early neonatal epoch (week 1): SNAP-II ≥30, confirmed early bactaeremia, confirmed tracheal infection, receipt of surfactant, hydrocortisone, dexamethasone, analgesic, sedation or vitamin A, mechanical ventilation. Late neonatal epoch (weeks 2–4): confirmed bactaeremia, confirmed tracheal infection, receipt of hydrocortisone, dexamethasone, analgesics, sedation or vitamin A, patent ductus arteriosus, PTX, PIE.
BW, birth weight; EPPD, early and persistent pulmonary dysfunction; FI, fetal indication; FiO2, fraction of inspired oxygen; GA, gestational age; Low FiO2 group, group with relatively normal pulmonary function; PD, pulmonary deterioration; PE, preeclampsia; PIE, pulmonary interstitial emphysema; PTX, pneumothorax; SNAP-II, Score for Neonatal Acute Physiology-II.