Table 4

Univariate associations between placenta histological characteristics and the risk of chronic lung disease

Respiratory pattern
Placenta histologyLow FiO2PDEPPDRow N
Inflammation, chorionic plate*Yes124875212
No195369895
Inflammation, chorion/deciduasYes85375411
No255167696
Neutrophilic infiltration, fetal stem vesselsYes155781274
No195067814
Umbilical cord vasculitisYes115373181
No205070901
Thrombosis of fetal stem vesselsYes40627758
No1752701039
InfarctYes325675190
No155169927
Increased syncytial knotsYes405976223
No135069898
Decidual haemorrhage/fibrin depositionYes254872182
No175270923
Per cent CLD18527052
Maximum column N2274294701026
  • The right-most column gives the maximum number of infants with the attribute listed in each row; any differences are due to missing data. All other data are the percentage of infants with CLD among those infants with the attribute listed in the two left columns and the respiratory patterns listed as column headings. For example, among infants who had inflammation of the chorionic plate and who had the Low FiO2 respiratory pattern, the prevalence of CLD was 12%.

  • * Stage 3 and severity 3.

  • Grades 3 and 4.

  • Grades 3, 4 and 5.

  • CLD, chronic lung disease; EPPD, early and persistent pulmonary dysfunction; FiO2, fraction of inspired oxygen; PD, pulmonary deterioration.